Survival in Patients with High-Grade Colorectal Neuroendocrine Carcinomas: The Role of Surgery and Chemotherapy

• Published in: Annals of surgical oncology Vol. 26; no. 4; pp. 1127 - 1133
• Main Authors: Fields, Adam C., Lu, Pamela, Vierra, Benjamin M., Hu, Frances, Irani, Jennifer, Bleday, Ronald, Goldberg, Joel E., Nash, Garrett M., Melnitchouk, Nelya
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2019; Springer Nature B.V
• Subjects: Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Carcinoma, Large Cell - mortality; Carcinoma, Large Cell - pathology; Carcinoma, Large Cell - surgery; Carcinoma, Neuroendocrine - mortality; Carcinoma, Neuroendocrine - pathology; Carcinoma, Neuroendocrine - surgery; Carcinoma, Small Cell - mortality; Carcinoma, Small Cell - pathology; Carcinoma, Small Cell - surgery; Chemotherapy; Colon; Colorectal Cancer; Colorectal carcinoma; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Colorectal Neoplasms - surgery; Colorectal Surgery - mortality; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Male; Malignancy; Medicine; Medicine & Public Health; Metastases; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - surgery; Neuroendocrine tumors; Oncology; Patients; Prospective Studies; Rectum; Risk factors; Surgery; Surgical Oncology; Survival; Survival Rate; Tumors
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-019-07203-3

Background Colorectal neuroendocrine tumors are a rare malignancy, yet their incidence appears to be increasing. The optimal treatment for the high-grade subset of these tumors remains unclear. We aimed to examine the relationship between different treatment modalities and outcomes for patients with high-grade neuroendocrine carcinomas (HGNECs) of the colon and rectum. Methods The National Cancer Database (2004–2015) was used to identify patients diagnosed with colorectal HGNECs. The primary outcome was overall survival. A Cox Proportional hazard model was used to identify risk factors for survival. Results Overall, 1208 patients had HGNECs; 452 (37.4%) patients had primary tumors of the rectum, and 756 (62.5%) patients had primary tumors of the colon. A total of 564 (46.7%) patients presented with stage IV disease. The median survival was 9.0 months [95% confidence interval (CI) 8.2–9.8]. In multivariable analysis, surgical resection [hazard ratio (HR) 0.54, 95% CI 0.44–0.66; p  < 0.001], chemotherapy (HR 0.74, 95% CI 0.69–0.79; p  < 0.001), and rectum as the primary site of tumor (HR 0.62, 95% CI 0.51–0.76; p  < 0.001) were associated with better overall survival, while older age (HR 1.01, 95% CI 1.00–1.01; p  = 0.02) and the presence of metastatic disease (HR 3.34, 95% CI 2.69–4.15; p  < 0.001) were associated with worse survival. Conclusions Patients with colorectal HGNECs selected for chemotherapy and surgical resection of the primary tumor demonstrated better overall survival than those managed without resection. Patients who were able to undergo systemic chemotherapy may benefit from potentially curative resection of the primary tumor.