Polysomnographic characteristics of adolescents with asthma and low risk for sleep-disordered breathing

• Published in: Sleep & breathing Vol. 23; no. 3; pp. 943 - 951
• Main Authors: Khassawneh, Basheer, Tsai, Sheila C., Meltzer, Lisa J.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2019; Springer Nature B.V
• Subjects: Adolescents; Apnea; Arousal; Asthma; Body mass index; Dentistry; Internal Medicine; Medicine; Medicine & Public Health; Neurology; Otorhinolaryngology; Pediatrics; Pediatrics • Original Article; Pneumology/Respiratory System; Questionnaires; REM sleep; Respiration; Sleep and wakefulness; Sleep disorders; Teenagers; Adolescence; Sleep; Children; Polysomnography; Sleep-disordered breathing; Asthma
• ISSN: 1520-9512; 1522-1709
• DOI: 10.1007/s11325-018-01774-3

Purpose The aim of this study was to describe the polysomnographic characteristics of adolescents with asthma who are at low risk for sleep-disordered breathing (SDB) based on the Pediatric Sleep Questionnaire (PSQ). Methods Overnight polysomnography was performed on 85 adolescents with asthma and a score < 0.33 on the PSQ. The Asthma Control Questionnaire was used to define “well-controlled” versus “inadequately controlled” asthma. Results Mean age of participants was 14.5 ± 1.6 years (range, 11 to 17 years), 63.5% were girls, 57.6% were Caucasians, and the mean body mass index percentile was 65.1 ± 26.5. Asthma was well-controlled in 51.7% of the adolescents and inadequately controlled in 15.3%. Mean sleep efficiency (SE) was 88.0 ± 11.1%, and 24.7% had SE < 85%. Mean wakefulness after sleep onset (WASO) was 40.9 ± 44.0 min, and the mean arousal index was 10.8 ± 5.6 per hour. The mean apnea/hypopnea index (AHI) was 2.3 ± 4.2, and 29.4% of participants had SDB (defined by an AHI ≥ 2). Compared with normative values, adolescents with asthma had more nocturnal awakenings and WASO, and less REM sleep. SDB risk was higher in boys [odds ratio = 4.6 (confidence interval 1.4–14.7), p  = 0.01]. Asthma control did not impact sleep and respiratory parameters, with no differences found between youth with well-controlled and inadequately controlled asthma. Conclusions Adolescents with asthma are at increased risk of sleep-disordered breathing and suffer from disturbances in sleep continuity with more arousals and sleep fragmentation. Study results highlight the importance of proper screening for sleep-disordered breathing in adolescents with asthma.