The structure proposed for apteniol D is different from that of the compound obtained by total synthesis

We describe the synthesis of 4,4′-oxyneolignan, the proposed structure for naturally occurring apteniol D. The diphenyl ether moiety in 4,4′-oxyneolignan was formed via classical Ullmann ether synthesis using excess copper powder in N,N-dimethylacetamide. The spectral data of synthesised apteniol D...

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Bibliographic Details
Published inNatural product research Vol. 31; no. 2; pp. 163 - 168
Main Authors Noshita, Toshiro, Matsumoto, Kohei, Nishikawa, Hikaru, Ouchi, Hidekazu, Hamada, Yoshitomo, Saito, Akiko, Yamada, Teiko
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.01.2017
Taylor & Francis Ltd
Subjects
Aizoaceae - chemistry
Aptenia cordifolia
apteniol
Diphenyl ether
Ethers - chemistry
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Mass Spectrometry
Phenyl Ethers - chemistry
Powder
Spectrophotometry, Infrared
Synthesis
Ullmann ether synthesis
apteniol
Aptenia cordifolia
diphenyl ether
Ullmann ether synthesis
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Summary:We describe the synthesis of 4,4′-oxyneolignan, the proposed structure for naturally occurring apteniol D. The diphenyl ether moiety in 4,4′-oxyneolignan was formed via classical Ullmann ether synthesis using excess copper powder in N,N-dimethylacetamide. The spectral data of synthesised apteniol D show differences compared to those of naturally occurring apteniol D.
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2016.1224867