Exercise-Induced Mitophagy in Skeletal Muscle and Heart

Regular exercise enhances mitochondrial function by promoting healthy mitochondrial remodeling, but the underlying mechanisms are not thoroughly understood. An emerging hypothesis suggests that, in addition to anabolic events such as mitochondria biogenesis, the selective degradation of dysfunctiona...

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Bibliographic Details
Published inExercise and sport sciences reviews Vol. 47; no. 3; p. 151
Main Authors Guan, Yuntian, Drake, Joshua C, Yan, Zhen
Format Journal Article
LanguageEnglish
Published United States 01.07.2019
Subjects
Adaptation, Physiological
Exercise - physiology
Humans
Mitochondria, Heart - physiology
Mitochondria, Muscle - physiology
Mitophagy
Muscle, Skeletal - physiology
Physical Conditioning, Human
Protein Kinases - physiology
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Summary:Regular exercise enhances mitochondrial function by promoting healthy mitochondrial remodeling, but the underlying mechanisms are not thoroughly understood. An emerging hypothesis suggests that, in addition to anabolic events such as mitochondria biogenesis, the selective degradation of dysfunctional mitochondria (i.e., mitophagy) also is a key component of exercise-mediated adaptations in striated muscle, which eventually leads to better mitochondrial functions.
ISSN:1538-3008
DOI:10.1249/jes.0000000000000192