Diagnostic performance of Japan NBI Expert Team classification for differentiation among noninvasive, superficially invasive, and deeply invasive colorectal neoplasia

• Published in: Gastrointestinal endoscopy Vol. 86; no. 4; pp. 700 - 709
• Main Authors: Sumimoto, Kyoku, MD, Tanaka, Shinji, MD, PhD, Shigita, Kenjiro, MD, Hayashi, Nana, MD, PhD, Hirano, Daiki, MD, Tamaru, Yuzuru, MD, Ninomiya, Yuki, MD, Oka, Shiro, MD, PhD, Arihiro, Koji, MD, PhD, Shimamoto, Fumio, MD, PhD, Yoshihara, Masaharu, MD, PhD, Chayama, Kazuaki, MD, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2017
• Subjects: Adenoma - classification; Adenoma - diagnostic imaging; Adenoma - pathology; Adenomatous Polyps - classification; Adenomatous Polyps - diagnostic imaging; Adenomatous Polyps - pathology; Carcinoma - classification; Carcinoma - diagnostic imaging; Carcinoma - pathology; Colonic Polyps - classification; Colonic Polyps - diagnostic imaging; Colonic Polyps - pathology; Colonoscopy; Colorectal Neoplasms - classification; Colorectal Neoplasms - diagnostic imaging; Colorectal Neoplasms - pathology; Gastroenterology and Hepatology; Humans; Intestinal Mucosa - pathology; Japan; Narrow Band Imaging; Neoplasm Invasiveness; HGD; hyperplastic polyp; sessile serrated polyp; Japan NBI Expert Team; superficial submucosal invasive carcinoma; HP; LGD; NICE classification; NBI International Colorectal Endoscopic classification; SM-d carcinoma; low-grade dysplasia; JNET; SSP; NBI; narrow-band imaging; high-grade dysplasia; deep submucosal invasive carcinoma; SM-s carcinoma
• ISSN: 0016-5107; 1097-6779
• DOI: 10.1016/j.gie.2017.02.018

Backgrounds and Aims The Japan NBI Expert Team (JNET) classification is the first universal narrow-band imaging magnifying endoscopic classification of colorectal tumors. Considering each type in this classification, the diagnostic ability of Type 2B is the weakest. Generally, clinical behavior is believed to be different in each gross type of colorectal tumor. We evaluated the differences in the diagnostic performance of JNET classification for each gross type (polypoid and superficial) and examined whether the diagnostic performance of Type 2B could be improved by subtyping. Methods We analyzed 2933 consecutive cases of colorectal lesions, including 136 hyperplastic polyps/sessile serrated polyps, 1926 low-grade dysplasias (LGDs), 571 high-grade dysplasias (HGDs), and 300 submucosal (SM) carcinomas. We classified lesions as polypoid and superficial type and compared the diagnostic performance of the classification system in each type. Additionally, we subtyped Type 2B into 2B-low and 2B-high based on the level of irregularity in surface and vessel patterns, and we evaluated the relationship between the subtypes and histology, as analyzed separately for polypoid and superficial types. We also estimated interobserver and intraobserver variability. Results The diagnostic performance of JNET classification did not differ significantly between polypoid and superficial lesions. Ninety-nine percent of Type 2B-low lesions were LGDs, HGDs, or superficial submucosal invasive (SM-s) carcinomas. In contrast, 60% of Type 2B-high lesions were deep submucosal invasive (SM-d) carcinomas. The results were not different between each gross type. Interobserver and intraobserver agreements for Type 2B subtyping were good, with kappa values of .743 and .786, respectively. Conclusions Type 2B subtyping may be useful for identifying lesions that are appropriate for endoscopic resection. JNET classification and Type 2B sub classification are useful criteria, regardless of gross type.