Association between P2X3 receptors and neuropathic pain: As a potential therapeutic target for therapy

• Published in: Biomedicine & pharmacotherapy Vol. 150; p. 113029
• Main Authors: Dong, Cai-rong, Zhang, Wen-jun, Luo, Hong-liang
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.06.2022; Elsevier
• Subjects: ATP; Chronic pain; Nervous system; Neuropathic pain; P2X3 receptor; CINC-1; IL; PKA; PKC; Nervous system; P2X3R; Chronic pain; NPP; Neuropathic pain; TNF-α; ATP; ERK; P2X3 receptor
• ISSN: 0753-3322; 1950-6007
• DOI: 10.1016/j.biopha.2022.113029

Neuropathic pain is a common clinical symptom of various diseases, and it seriously affects the physical and mental health of patients. Owing to the complex pathological mechanism of neuropathic pain, clinical treatment of pain is challenging. Therefore, there is growing interest among researchers to explore potential therapeutic strategies for neuropathic pain. A large number of studies have shown that development of neuropathic pain is related to nerve conduction and related signaling molecules. P2X3 receptors (P2X3R) are ATP-dependent ion channels that participate in the transmission of neural information and related signaling pathways, sensitize the central nervous system, and play a key role in the development of neuropathic pain. In this paper, we summarized the structure and biological characteristics of the P2X3R gene and discussed the role of P2X3R in the nervous system. Moreover, we outlined the related pathological mechanisms of pain and described the relationship between P2X3R and chronic pain to provide valuable information for development of novel treatment strategies for pain.