Impact of fentanyl in lieu of meperidine on endoscopy unit efficiency: a prospective comparative study in patients undergoing EGD

• Published in: Gastrointestinal endoscopy Vol. 77; no. 6; pp. 883 - 887
• Main Authors: Dzeletovic, Ivana, MD, Harrison, M. Edwyn, MD, Crowell, Michael D., PhD, Ramirez, Francisco C., MD, Yows, Catherine R., RN, Harris, Lucinda A., MD, Pasha, Shabana F., MD, Gurudu, Suryakanth R., MD, Leighton, Jonathan A., MD, Heigh, Russell I., MD
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.06.2013
• Subjects: Adjuvants, Anesthesia - therapeutic use; Adult; Aged; Cohort Studies; Conscious Sedation - methods; Endoscopy, Digestive System - methods; Female; Fentanyl - therapeutic use; Gastroenterology and Hepatology; Humans; Hypnotics and Sedatives - therapeutic use; Male; Meperidine - therapeutic use; Midazolam - therapeutic use; Middle Aged; Prospective Studies; Time Factors
• ISSN: 0016-5107; 1097-6779
• DOI: 10.1016/j.gie.2013.01.013

Background Turnaround time is an important component of endoscopy unit efficiency. Any reduction in the total time from patient arrival in the endoscopy room to departure from the recovery area may translate into better endoscopy unit efficiency. Objective To evaluate the effects on endoscopy unit efficiency of a change in narcotic choice for moderate sedation in patients undergoing EGD at an ambulatory surgery center. Design Prospective, comparative, quality-improvement project. Setting Endoscopy unit of a tertiary-care academic medical center. Patients We enrolled consecutive patients (n = 1963) who underwent outpatient EGD by 1 of 5 endoscopists between November 2008 and November 2010. Intervention Moderate sedation with midazolam plus fentanyl versus meperidine. Main Outcome Measurements Sedation-dependent endoscopy unit efficiency and total procedure time (induction-to-intubation, intubation-to-extubation, and extubation-to-discharge). Results Fentanyl was associated with reduced total procedure time by 10.1 minutes resulting from both shorter induction-to-intubation time and extubation-to-discharge time ( P < .001). The mean (± SD) sedation-dependent endoscopy unit efficiency was 3.2 (± 1.9) procedures per hour for the meperidine group and 3.9 (± 2.7) procedures per hour for the fentanyl group ( P = .012); this would translate into possibly increasing the endoscopy suite efficiency by 22%. Based on dosage equivalency conversion, equal doses of fentanyl and meperidine were used. No sedation-related complications or need for reversal agents were recorded. Limitations No randomization was performed. Conclusion Compared with meperidine, fentanyl in combination with midazolam was associated with significantly shorter total procedure time. By improving the turnaround time, sedation-dependent endoscopy unit efficiency may be improved by 22%.