The annexinopathies: a new category of diseases

The annexins are a family of highly homologous phospholipid binding proteins, which share a four-domain structure, with one member of the family – annexin VI – having a duplication consisting of eight domains. Thus far, ten annexins have been described in mammals. Although the biological functions o...

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Bibliographic Details
Published inBBA - Molecular Cell Research Vol. 1498; no. 2; pp. 169 - 173
Main Author Rand, Jacob H.
Format Book Review Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 20.12.2000
Subjects
Acute promyelocytic leukemia
Animals
Annexin
Annexin A2 - biosynthesis
Annexin A2 - genetics
Annexin A5 - deficiency
Annexin A5 - genetics
Annexin A7 - deficiency
Annexin A7 - genetics
Antiphospholipid antibody
Antiphospholipid syndrome
Antiphospholipid Syndrome - genetics
Calcium - metabolism
Calcium Channels - deficiency
Disease Models, Animal
Endothelium
Female
Fibrinolysis
Humans
Inositol 1,4,5-Trisphosphate Receptors
Insulin - metabolism
Leukemia, Promyelocytic, Acute - genetics
Phospholipid
Placenta
Pre-Eclampsia - genetics
Pregnancy
Receptors, Cytoplasmic and Nuclear - deficiency
Acute promyelocytic leukemia
Placenta
Phospholipid
Antiphospholipid antibody
Fibrinolysis
Annexin
Antiphospholipid syndrome
Endothelium
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Summary:The annexins are a family of highly homologous phospholipid binding proteins, which share a four-domain structure, with one member of the family – annexin VI – having a duplication consisting of eight domains. Thus far, ten annexins have been described in mammals. Although the biological functions of the annexins have not been definitively established, two human diseases involving annexin abnormalities (‘annexinopathies’) have been identified as of the time of writing. Overexpression of annexin II occurs in the leukocytes of a subset of patients having a hemorrhagic form of acute promyelocytic leukemia. Underexpression of annexin V occurs on placental trophoblasts in the antiphospholipid syndrome and in preeclampsia. Also, an animal model has been described in which annexin VII is underexpressed and is associated with disease, but the relevance of this animal model to human disease is not yet understood. Future research is likely to elucidate additional ‘annexinopathies’.
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ISSN:0167-4889
0006-3002
1879-2596
DOI:10.1016/S0167-4889(00)00093-8