Galectin-1 is associated with the severity of coronary artery disease and adverse cardiovascular events in patients undergoing coronary angiography

• Published in: Scientific reports Vol. 10; no. 1; p. 20683
• Main Authors: Chou, Ruey-Hsing, Huang, Shao-Sung, Kuo, Chin-Sung, Wang, Shen-Chih, Tsai, Yi-Lin, Lu, Ya-Wen, Chang, Chun-Chin, Huang, Po-Hsun, Lin, Shing-Jong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.11.2020; Nature Publishing Group
• Subjects: 692/4019; 692/53; Aged; Aged, 80 and over; Angiography; C-reactive protein; C-Reactive Protein - metabolism; Cardiovascular disease; Cardiovascular System - metabolism; Cardiovascular System - pathology; Congestive heart failure; Coronary Angiography - methods; Coronary artery; Coronary artery disease; Coronary Artery Disease - metabolism; Coronary Artery Disease - pathology; Coronary vessels; Creatinine; Diabetes mellitus; Diabetes Mellitus - metabolism; Diabetes Mellitus - pathology; Female; Galectin 1 - metabolism; Galectin-1; Heart Failure - metabolism; Heart Failure - pathology; Hemoglobin; Humanities and Social Sciences; Humans; Hypertension; Hypertension - metabolism; Hypertension - pathology; Kidney diseases; Male; Medical imaging; Middle Aged; multidisciplinary; Myocardial infarction; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Renal failure; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - pathology; Science; Science (multidisciplinary); Serum levels; Severity of Illness Index; Vascularization; Ventricle
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-77804-6

Galectin-1, a β-galactoside-binding lectin mediating inflammation and neovascularization, is reported to attenuate ventricular remodeling after myocardial infarction. But its role in stable coronary artery disease (CAD) has not been fully elucidated. This study aimed to identify the relationship between the circulating galectin-1 level and the severity of CAD in patients with suspected CAD. Pre-procedure galectin-1 and high-sensitivity C-reactive protein (hs-CRP) concentrations were measured in 834 subjects who underwent scheduled coronary angiography. Subjects were grouped into tertiles of the galectin-1 levels. SYNTAX scores were calculated to evaluate the severity of CAD. All patients were followed until January 2019 or the occurrence of major adverse cardiovascular events (MACE). Patients with higher galectin-1 concentrations were older; had greater prevalence of hypertension, diabetes, chronic kidney disease, and heart failure; and were more likely to present with higher hs-CRP levels and SYNTAX scores. During the follow-up period of 1.3 ± 1.1 years, patients in the highest tertile of galectin-1 were associated with a greater risk of MACE after adjustment for age, sex, comorbidities, co-medications, serum levels of hemoglobin, creatinine, hs-CRP, ejection fraction, SYNTAX scores, and revascularization modalities (adjusted hazard ratio 10.95, 95% confidence interval 2.29–52.47, p  = 0.003). Galectin-1 showed better discriminatory performance than hs-CRP, and non-inferior performance to SYNTAX scores, in predicting the incidence of MACE.