Duration of noninvasive respiratory support and risk for bronchopulmonary dysplasia or death

Objective To determine whether the duration of noninvasive respiratory support exposure is associated with bronchopulmonary dysplasia (BPD) or death in preterm infants. Methods Multicenter, retrospective study of infants born at <29 weeks’ gestation. The association between days on noninvasive re...

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Bibliographic Details
Published inJournal of perinatology Vol. 42; no. 4; pp. 454 - 460
Main Authors Gentle, Samuel J., Carper, Benjamin, Laughon, Matthew M., Jensen, Erik A., Williams, Austin, Travers, Colm P., Ambalavanan, Namasivayam, Lal, Charitharth V., Carlo, Waldemar A.
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.04.2022
Nature Publishing Group
Subjects
692/499
692/699/1785
Bronchopulmonary Dysplasia - complications
Death
Dysplasia
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Premature
Infants
Lung diseases
Matching
Medicine
Medicine & Public Health
Mortality
Pediatric Surgery
Pediatrics
Respiratory Rate
Retrospective Studies
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Summary:Objective To determine whether the duration of noninvasive respiratory support exposure is associated with bronchopulmonary dysplasia (BPD) or death in preterm infants. Methods Multicenter, retrospective study of infants born at <29 weeks’ gestation. The association between days on noninvasive respiratory support and BPD or death was determined using instrumental variable techniques and generalized propensity score matching to account for potential confounding by illness severity. Results Among 6268 infants 36% developed BPD or died. The median duration of noninvasive respiratory support was 18 days. There was inconsistency in the association between noninvasive support and BPD or death when analyzed by instrumental variable techniques (Average Marginal Effect −0.37; 95% CI −1.23 to 0.50) and generalized propensity score matching (Average Marginal Effect 0.46; 95% CI 0.33 to 0.60). Conclusion Findings on the association between duration of exposure to noninvasive respiratory support and the development of BPD or death were inconclusive. ClinicalTrials.gov ID Generic Database:NCT00063063.
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Matthew M Laughon assisted with analyses, conceptualization of the study, and reviewed and revised the manuscript.
Waldemar A. Carlo assisted with analyses, conceptualization of the study, and reviewed and revised the manuscript.
Austin Williams conducted the statistical analyses, assisted with analyses, conceptualization of the study, and reviewed and revised the manuscript.
Namasivayam Ambalavanan assisted with analyses, conceptualization of the study, and reviewed and revised the manuscript.
Erik A Jensen assisted with analyses, conceptualization of the study, and reviewed and revised the manuscript.
Contributors’ Statement Page
Colm P Travers assisted with analyses, conceptualization of the study, and reviewed and revised the manuscript.
Samuel J. Gentle conceptualized and implemented this study, performed initial analyses, drafted the manuscript, and reviewed and revised the manuscript.
All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.
Benjamin Carper conceptualized the study, conducted the statistical analyses, and reviewed and revised the manuscript.
Charitharth V Lal assisted with analyses, conceptualization of the study, and reviewed and revised the manuscript.
ISSN:0743-8346
1476-5543
1476-5543
DOI:10.1038/s41372-021-01269-2