Dry eye syndrome: comprehensive etiologies and recent clinical trials

Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than ever given the rapid pace of modernization, which is directly associated with many of the extrinsic causative factors. Additionally, recent studies have also postulated novel etiologies that may provide the bas...

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Published inInternational ophthalmology Vol. 42; no. 10; pp. 3253 - 3272
Main Authors Huang, Ruojing, Su, Caiying, Fang, Lvjie, Lu, Jiaqi, Chen, Jiansu, Ding, Yong
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.10.2022
Springer Nature B.V
Subjects
Clinical trials
Cornea
Etiology
Exocrine glands
Eye diseases
Eye surgery
Lipids
Lymphocytes
Medicine
Medicine & Public Health
Modernization
Ophthalmology
Review
Signal transduction
Systemic diseases
Thyroid gland
Dry eye syndrome
Lacrimal functional unit
Ophthalmology
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Abstract Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than ever given the rapid pace of modernization, which is directly associated with many of the extrinsic causative factors. Additionally, recent studies have also postulated novel etiologies that may provide the basis for alternative treatment methods clinically. Such insights are especially important given that current approaches to tackle DES remains suboptimal. This review will primarily cover a comprehensive list of causes that lead to DES, summarize all the upcoming and ongoing clinical trials that focuses on treating this disease as well as discuss future potential treatments that can improve inclusivity.
AbstractList Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than ever given the rapid pace of modernization, which is directly associated with many of the extrinsic causative factors. Additionally, recent studies have also postulated novel etiologies that may provide the basis for alternative treatment methods clinically. Such insights are especially important given that current approaches to tackle DES remains suboptimal. This review will primarily cover a comprehensive list of causes that lead to DES, summarize all the upcoming and ongoing clinical trials that focuses on treating this disease as well as discuss future potential treatments that can improve inclusivity.
Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than ever given the rapid pace of modernization, which is directly associated with many of the extrinsic causative factors. Additionally, recent studies have also postulated novel etiologies that may provide the basis for alternative treatment methods clinically. Such insights are especially important given that current approaches to tackle DES remains suboptimal. This review will primarily cover a comprehensive list of causes that lead to DES, summarize all the upcoming and ongoing clinical trials that focuses on treating this disease as well as discuss future potential treatments that can improve inclusivity.Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than ever given the rapid pace of modernization, which is directly associated with many of the extrinsic causative factors. Additionally, recent studies have also postulated novel etiologies that may provide the basis for alternative treatment methods clinically. Such insights are especially important given that current approaches to tackle DES remains suboptimal. This review will primarily cover a comprehensive list of causes that lead to DES, summarize all the upcoming and ongoing clinical trials that focuses on treating this disease as well as discuss future potential treatments that can improve inclusivity.
Author Ding, Yong
Su, Caiying
Huang, Ruojing
Fang, Lvjie
Lu, Jiaqi
Chen, Jiansu
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  orcidid: 0000-0002-6983-1027
  surname: Ding
  fullname: Ding, Yong
  email: dingyong@jnu.edu.cn
  organization: Department of Ophthalmology, The First Affiliated Hospital of Jinan University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35678897$$D View this record in MEDLINE/PubMed
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IngestDate Thu Aug 21 18:02:23 EDT 2025
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Wed Feb 19 02:25:45 EST 2025
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Thu Apr 24 23:11:10 EDT 2025
Thu Apr 10 07:06:22 EDT 2025
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Issue 10
Keywords Dry eye syndrome
Lacrimal functional unit
Ophthalmology
Language English
License 2022. The Author(s), under exclusive licence to Springer Nature B.V.
This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
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SubjectTerms Clinical trials
Cornea
Etiology
Exocrine glands
Eye diseases
Eye surgery
Lipids
Lymphocytes
Medicine
Medicine & Public Health
Modernization
Ophthalmology
Review
Signal transduction
Systemic diseases
Thyroid gland
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Title Dry eye syndrome: comprehensive etiologies and recent clinical trials
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