Dry eye syndrome: comprehensive etiologies and recent clinical trials

Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than ever given the rapid pace of modernization, which is directly associated with many of the extrinsic causative factors. Additionally, recent studies have also postulated novel etiologies that may provide the bas...

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Published inInternational ophthalmology Vol. 42; no. 10; pp. 3253 - 3272
Main Authors Huang, Ruojing, Su, Caiying, Fang, Lvjie, Lu, Jiaqi, Chen, Jiansu, Ding, Yong
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.10.2022
Springer Nature B.V
Subjects
Clinical trials
Cornea
Etiology
Exocrine glands
Eye diseases
Eye surgery
Lipids
Lymphocytes
Medicine
Medicine & Public Health
Modernization
Ophthalmology
Review
Signal transduction
Systemic diseases
Thyroid gland
Dry eye syndrome
Lacrimal functional unit
Ophthalmology
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Summary:Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than ever given the rapid pace of modernization, which is directly associated with many of the extrinsic causative factors. Additionally, recent studies have also postulated novel etiologies that may provide the basis for alternative treatment methods clinically. Such insights are especially important given that current approaches to tackle DES remains suboptimal. This review will primarily cover a comprehensive list of causes that lead to DES, summarize all the upcoming and ongoing clinical trials that focuses on treating this disease as well as discuss future potential treatments that can improve inclusivity.
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ISSN:1573-2630
0165-5701
1573-2630
DOI:10.1007/s10792-022-02320-7