Congenital Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor: A Case Report and Review of the Literature

• Published in: Pediatrics and neonatology Vol. 57; no. 5; pp. 436 - 439
• Main Authors: Jin, Shu-Guang, Jiang, Xiao-Ping, Zhong, Lin
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier 01.10.2016
• Subjects: Bone Neoplasms - congenital; Bone Neoplasms - pathology; Bone Neoplasms - therapy; diagnosis; Ewing's sarcoma; Female; Humans; Immunohistochemistry; Infant, Newborn; Internal Medicine; Neuroectodermal Tumors, Primitive, Peripheral - congenital; Neuroectodermal Tumors, Primitive, Peripheral - pathology; Neuroectodermal Tumors, Primitive, Peripheral - therapy; newborn; Pediatrics; peripheral primitive neuroectodermal tumor; prognosis; Sarcoma, Ewing - congenital; Sarcoma, Ewing - pathology; Sarcoma, Ewing - therapy; treatment; treatment; diagnosis; peripheral primitive neuroectodermal tumor; newborn; prognosis; Ewing's sarcoma
• ISSN: 1875-9572; 2212-1692
• DOI: 10.1016/j.pedneo.2013.11.002

Ewing's sarcoma (EWS) and peripheral primitive neuroectodermal tumor (pPNET) are small round cell malignancies that develop in soft tissue and bone. They very rarely affect newborns. A diagnosis of EWS/pPNET depends mainly on immunohistochemistry and molecular/genetic assays. Since these tumors are highly aggressive, patient prognosis is typically very poor, and treatment remains a challenge. Here, we report a 13-day-old newborn diagnosed with congenital EWS/pPNET and describe its treatment.