A Pro‐Metastatic Derivatives Eliminator for In Vivo Dual‐Removal of Circulating Tumor Cells and Tumor‐Derived Exosomes Impedes their Biodistribution into Distant Organs

• Published in: Advanced science Vol. 10; no. 34; pp. e2304287 - n/a
• Main Authors: Sun, Ying, Xing, Lei, Luo, Jun, Yu, Ming‐Tao, Wang, Xiao‐Jie, Wang, Yi, Zhou, Tian‐Jiao, Jiang, Hu‐Lin
• Format: Journal Article
• Language: English
• Published: Germany John Wiley & Sons, Inc 01.12.2023; Wiley
• Subjects: Antibodies; Biodistribution; Cancer therapies; Catheters; circulating tumor cells; dual removal; Efficiency; Exosomes - metabolism; hemoperfusion; Humans; Lung - pathology; Metastasis; metastatic cascade; Nanomaterials; Neoplasm Recurrence, Local - metabolism; Neoplastic Cells, Circulating - metabolism; Neoplastic Cells, Circulating - pathology; Seeds; Tissue Distribution; tumor‐derived exosomes; hemoperfusion; biodistribution; metastatic cascade; circulating tumor cells; tumor-derived exosomes; dual removal
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202304287

Circulating tumor cells (CTCs) and tumor‐derived exosomes (TDEs) play an irreplaceable role in the metastatic cascade and preventing them from reaching distant organs via blood circulation helps to reduce the probability of cancer recurrence and metastasis. However, technologies that can simultaneously prevent CTCs and TDEs from reaching distant organs have not been thoroughly developed until now. Here, inspired by hemoperfusion, a pro‐metastatic derivative eliminator (PMDE) is developed for the removal of both CTCs and TDEs from the peripheral blood, which also inhibits their biodistribution in distant organs. This device is designed with a dual antibody‐modified immunosorbent filled into a capture column that draws peripheral blood out of the body to flow through the column to specifically capture CTCs and TDEs, followed by retransfusing the purified blood into the body. The PMDE can efficiently remove CTCs and TDEs from the peripheral blood and has excellent biocompatibility. Interestingly, the PMDE device can significantly inhibit the biodistribution of CTCs and TDEs in the lung and liver by scavenging them. This work provides a new perspective on anti‐metastatic therapy and has broad prospects in clinical applications to prevent metastasis and recurrence. CTCs and TDEs are organotropic to reach specific distant organs through blood circulation. TDEs are like fertilizers to make the soil (pre‐metastatic niche) fertile for seed (CTCs) growth. The proposed pro‐metastatic derivatives eliminator (PMDE) can inhibits the biodistribution of CTCs and TDEs to distant organs by efficiently capturing and removing them from peripheral blood.