Genetic Variants of the IL‐23/IL‐17 Axis and Its Association With Periodontal Disease: A Systematic Review

• Published in: Immunity, Inflammation and Disease Vol. 13; no. 2; pp. e70147 - n/a
• Main Authors: Rodríguez‐Montaño, Ruth, Alarcón‐Sánchez, Mario Alberto, Lomelí‐Martínez, Sarah Monserrat, Martínez‐Bugarin, Cristina Hermila, Heboyan, Artak
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2025; John Wiley and Sons Inc; Wiley
• Subjects: Adult; Coronaviruses; COVID-19; Cytokines; Fibroblasts; Genes; Genetic Predisposition to Disease; Genetic Variation; Gum disease; Humans; IL‐17; IL‐23; Interleukin-17 - genetics; Interleukin-23 - genetics; Kinases; Lymphocytes; Medical Subject Headings-MeSH; Microbiota; Periodontal Diseases - genetics; Periodontics; periodontitis; Periodontitis - genetics; peri‐implantitis; Polymorphism; Polymorphism, Single Nucleotide; Receptors, Interleukin - genetics; Receptors, Interleukin-17 - genetics; Review; Systematic review; Transplants & implants; Tumor necrosis factor-TNF; Vascular endothelial growth factor; IL‐23; peri‐implantitis; cytokines; IL‐17; genes; periodontitis
• ISSN: 2050-4527; 2050-4527
• DOI: 10.1002/iid3.70147

ABSTRACT Background The objective of this systematic review was to identify genetic variants of the IL‐23, IL‐17, IL‐23R and IL‐17R genes and isoforms and its possible association with increased development of periodontitis and peri‐implantitis. Methods A systematic review was prepared according to the guidelines, registered in the OSF database with the registration number: 10.17605/OSF. IO/X95ZC. The electronic search was performed in four databases: PubMed, Scopus, Web of Science, and Google Scholar from 1984 until March 15th, 2024. The JBI Critical Appraisal Checklist for Case‐Control Studies was used to assess the quality of included studies. Results Eighteen papers with a case‐control design were those that ultimately met the eligibility criteria. A total of 3904 individuals (2315 with periodontitis and 90 with peri‐implantitis), and 1589 healthy subjects) were studied. The age range of the study population was 14–70 years, with a mean age ± (SD) of 40.43 ± 6.33 years. A total of 28 genetic variants corresponding to the IL‐17A (rs 2275913, rs 3819024, rs 10484879) IL‐17F (rs 763780), IL‐17R (rs 879576) and IL‐23R (rs 11209026) genes were analyzed in this study. Six (33.3%) studies found an association between the IL‐17A 197 G/A (rs 2275913) genetic variant and peri‐implantitis and periodontitis. One study (5.5%) found an association between the IL‐17A rs10484879 variant and peri‐implantitis and periodontitis. Conclusion Six polymorphisms were evaluated, highlighting rs 2275913 of the cytokine IL‐17A in patients with periodontitis or peri‐implantitis. Only 50% of studies found an association despite having a small sample. This suggests that other factors such as the degree of disease, systemic diseases and ethnic groups studied may play a role.