Bacterial invasion via lipid rafts

Summary Accumulating reports document the use by pathogens of cholesterol‐enriched lipid microdomains, often called lipid rafts, as cell surface platforms to interact, bind and possibly enter into host cells. The challenge is now to understand what could be the functional role of these domains durin...

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Published inCellular microbiology Vol. 7; no. 5; pp. 613 - 620
Main Authors Lafont, Frank, Van Der Goot, F. Gisou
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Science Ltd 01.05.2005
Hindawi Limited
Subjects
Animals
Bacterial Adhesion
Bacterial Physiological Phenomena
Endocytosis
Humans
Membrane Microdomains - metabolism
Membrane Microdomains - microbiology
Signal Transduction
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Summary:Summary Accumulating reports document the use by pathogens of cholesterol‐enriched lipid microdomains, often called lipid rafts, as cell surface platforms to interact, bind and possibly enter into host cells. The challenge is now to understand what could be the functional role of these domains during pathogen invasion. Are they hijacked as general clustering devices for cellular binding sites and/or do they have other roles? In particular, is their cell signalling capacity activated and used by pathogens? In reverse, could lipid rafts activate bacterial mechanisms required for invasion? These issues will be discussed after an introduction on the current view on lipid rafts.
Bibliography:Institut Pasteur de Lille, 1 rue du Prof. Calmette, 59019, Lille, France.
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ISSN:1462-5814
1462-5822
DOI:10.1111/j.1462-5822.2005.00515.x