Radiolabeled Nanogels for Nuclear Molecular Imaging
An efficient and simple synthesis approach to form stable 68Ga‐labeled nanogels is reported and their fundamental properties investigated. Nanogels are obtained by self‐assembly of amphiphilic statistical prepolymers derivatised with chelating groups for radiometals. The resulting nanogels exhibit a...
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Published in | Macromolecular rapid communications. Vol. 34; no. 7; pp. 562 - 567 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
12.04.2013
WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | An efficient and simple synthesis approach to form stable 68Ga‐labeled nanogels is reported and their fundamental properties investigated. Nanogels are obtained by self‐assembly of amphiphilic statistical prepolymers derivatised with chelating groups for radiometals. The resulting nanogels exhibit a well‐defined spherical shape with a diameter of 290 ± 50 nm. The radionuclide 68Ga is chelated in high radiochemical yields in an aqueous medium at room temperature. The phagocytosis assay demonstrates a highly increased internalization of nanogels by activated macrophages. Access to these 68Ga‐nanogels will allow the investigation of general behavior and clearance pathways of nanogels in vivo by nuclear molecular imaging.
Biodegradable nanogels are prepared by crosslinking of amphiphilic, thiol‐functionalized star shaped P(EO‐stat‐PO). Incorporation of NODAGA, a chelating agent, in the prepolymer enabled the radiolabeling of nanogels with 68Ga for the purpose of investigation the in vivo behavior of nanogels. Nanogels are biocompatible and only ingested by macrophage on upregulation of phagocytosis capacity. |
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Bibliography: | ArticleID:MARC201200744 ark:/67375/WNG-FKSZH0C9-9 istex:B26B8672A8A36C44CE5042BC98E28FDD71F7838F ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1022-1336 1521-3927 |
DOI: | 10.1002/marc.201200744 |