Movie Events Detecting Reveals Inter-Subject Synchrony Difference of Functional Brain Activity in Autism Spectrum Disorder

• Published in: Frontiers in computational neuroscience Vol. 16; p. 877204
• Main Authors: Ou, Wenfei, Zeng, Wenxiu, Gao, Wenjian, He, Juan, Meng, Yufei, Fang, Xiaowen, Nie, Jingxin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 03.05.2022; Frontiers Media S.A
• Subjects: Autism; autism spectrum disorder (ASD); Brain mapping; Brain research; Cerebellum; Cortex (parietal); External stimuli; Functional magnetic resonance imaging; inter-Subject correlation (ISC); inter-Subject function correlation (ISFC); Magnetic resonance imaging; Medical imaging; Motion pictures; movie-watching fMRI; Neural networks; Neuroscience; Paradigms; Sensorimotor system; sliding windows; Social interaction; Temporal gyrus; Time series; inter-Subject correlation (ISC); inter-Subject function correlation (ISFC); autism spectrum disorder (ASD); movie-watching fMRI; sliding windows
• ISSN: 1662-5188; 1662-5188
• DOI: 10.3389/fncom.2022.877204

Recently, movie-watching fMRI has been recognized as a novel method to explore brain working patterns. Previous researchers correlated natural stimuli with brain responses to explore brain functional specialization by “reverse correlation” methods, which were based on within-group analysis. However, what external stimuli drove significantly different brain responses in two groups of different subjects were still unknown. To address this, sliding time windows technique combined with inter-Subject functional correlation (ISFC) was proposed to detect movie events with significant group differences between autism spectrum disorder (ASD) and typical development (TD) subjects. Then, using inter-Subject correlation (ISC) and ISFC analysis, we found that in three movie events involving character emotions, the ASD group showed significantly lower ISC in the middle temporal gyrus, temporal pole, cerebellum, caudate, precuneus, and showed decreased functional connectivity between large scale networks than that in TD. Under the movie event focusing on objects and scenes shot, the dorsal and ventral attentional networks of ASD had a strong synchronous response. Meanwhile, ASD also displayed increased functional connectivity between the frontoparietal network (FPN) and dorsal attention network (DAN), FPN, and sensorimotor network (SMN) than TD. ASD has its own unique synchronous response rather than being “unresponsive” in natural movie-watching. Our findings provide a new method and valuable insight for exploring the inconsistency of the brain “tick collectively” to same natural stimuli. This analytic approach has the potential to explore pathological mechanisms and promote training methods of ASD.