HPLC isolation of the anti-plasmodially active bisbenzylisoquinone alkaloids present in roots of Cissampelos mucronata
The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationar...
Saved in:
Published in | Phytochemical analysis Vol. 14; no. 1; pp. 13 - 22 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
2003
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationary and mobile phases. The active principles were determined to be a series of bisbenzylisoquinoline alkaloids, a group of natural products for which one of the first routine preparative HPLC separation methods is described. Copyright © 2003 John Wiley & Sons, Ltd. |
---|---|
AbstractList | The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationary and mobile phases. The active principles were determined to be a series of bisbenzylisoquinoline alkaloids, a group of natural products for which one of the first routine preparative HPLC separation methods is described. Abstract The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum . In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationary and mobile phases. The active principles were determined to be a series of bisbenzylisoquinoline alkaloids, a group of natural products for which one of the first routine preparative HPLC separation methods is described. Copyright © 2003 John Wiley & Sons, Ltd. The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationary and mobile phases. The active principles were determined to be a series of bisbenzylisoquinoline alkaloids, a group of natural products for which one of the first routine preparative HPLC separation methods is described. Copyright © 2003 John Wiley & Sons, Ltd. |
Author | König, Gabriele M. Wright, Anthony D. Tshibangu, Jeannette Ndaya |
Author_xml | – sequence: 1 fullname: Tshibangu, J.N – sequence: 2 fullname: Wright, A.D – sequence: 3 fullname: Konig, G.M |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12597251$$D View this record in MEDLINE/PubMed |
BookMark | eNp10Etv1DAUBWALFdFpQfwD8AoWKMXPZLwsA3SQBiiPCsTGuklsMHXikJspDL8ejzKCFSsv_N2jo3NCjvrUO0Luc3bGGRNPhwbOykreIgvOjCm4LvURWTCjlwWTSh2TE8TvjOU_U94hx1xoUwnNF-RmfblZ0YApwhRST5On0zdHoZ9CMUTALrUBYtxRaKZw42gdsHb9713MJz-2YV-DQryGmEKLdBgdun6ioadjShPu41YBEbrBxYS02zZj6mGCu-S2h4ju3uE9JVcvX3xcrYvN24tXq_NN0ahKycIz6cCouuWyZXXpG2-M4IJ56aWqtdAKGu2FbIA13CtRt95I6YVZKu1K38pT8mjOHcZc1-Fku4CNixF6l7ZoK8lUWSqR4eMZ5oKIo_N2GEMH485yZvcT2zyxzRNn-eAQua071_5zh00zeDKDnyG63f9y7OXqfI4rZh1wcr_-ahiv96rS9tObC_v63frZ5_flF_s8-4ez95AsfB0D2qsPgnHJOBNLWZXyD_kZoZA |
CitedBy_id | crossref_primary_10_1007_s00436_011_2638_3 crossref_primary_10_1016_j_jep_2007_08_033 crossref_primary_10_1038_nbt1033 crossref_primary_10_1002_pca_1376 crossref_primary_10_1016_j_jep_2014_06_054 crossref_primary_10_1002_pca_678 crossref_primary_10_1016_j_jep_2022_115130 crossref_primary_10_1039_b700306b crossref_primary_10_1002_cbdv_202100358 crossref_primary_10_1007_s11101_020_09695_4 crossref_primary_10_1007_s11101_015_9437_x crossref_primary_10_1021_np200700f crossref_primary_10_1186_s12936_023_04590_7 crossref_primary_10_1016_j_jep_2017_10_034 crossref_primary_10_1248_cpb_58_986 crossref_primary_10_1016_j_phytochem_2014_03_026 |
Cites_doi | 10.1039/jr9610001896 10.1016/S0031-9422(00)88152-2 10.1139/v89-045 10.1039/jr9530003893 10.1039/JR9400000737 10.1248/yakushi1947.72.10_1219 10.1021/jo00324a036 10.1002/jccs.197000030 10.1007/978-3-642-68773-0 10.1016/S0040-4039(01)95519-4 10.1021/jo950767n 10.1021/np50052a001 10.1021/np50001a001 10.1016/S0040-4020(01)90186-3 10.1016/S0040-4039(00)77898-1 10.1016/S0021-9673(97)01065-0 10.1039/c29700001020 10.1016/0040-4020(72)80168-6 10.1016/S0040-4039(00)70400-X 10.1016/S0040-4020(01)81727-0 10.1021/np970257j 10.1007/978-3-662-09141-8 10.1016/S0021-9673(98)00416-6 10.1021/np9702042 10.1055/s-2000-8610 10.1128/AAC.16.6.710 10.1021/np50025a001 10.1016/S0021-9673(00)00629-4 10.1128/AAC.40.8.1846 10.1021/np50075a001 10.1055/s-2007-969398 10.1021/np9700174 10.3891/acta.chem.scand.15-1130 10.1039/p29730000716 10.1016/S0378-8741(01)00409-3 10.1021/np9602527 10.1016/S0040-4039(00)00299-9 |
ContentType | Journal Article |
Copyright | Copyright © 2003 John Wiley & Sons, Ltd. |
Copyright_xml | – notice: Copyright © 2003 John Wiley & Sons, Ltd. |
DBID | FBQ BSCLL CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1002/pca.673 |
DatabaseName | AGRIS Istex Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic CrossRef |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Chemistry Botany |
EISSN | 1099-1565 |
EndPage | 22 |
ExternalDocumentID | 10_1002_pca_673 12597251 PCA673 ark_67375_WNG_MQHBXR6Z_D US201301028376 |
Genre | article Journal Article |
GeographicLocations | China Republic of the Congo |
GeographicLocations_xml | – name: China – name: Republic of the Congo |
GroupedDBID | --- .3N .GA .Y3 05W 0R~ 10A 123 1L6 1OB 1OC 1ZS 31~ 33P 3SF 3WU 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52S 52T 52U 52W 52X 53G 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A03 AAESR AAEVG AAHHS AAJUZ AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABCVL ABHUG ABIJN ABJNI ABPVW ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACIWK ACPOU ACPRK ACSCC ACXBN ACXME ACXQS ADAWD ADBBV ADDAD ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFRAH AFVGU AFZJQ AGJLS AHMBA AIAGR AIURR AIWBW AJBDE AJXKR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AUFTA AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMNLL BMXJE BNHUX BROTX BRXPI BY8 CS3 D-E D-F DCZOG DPXWK DR2 DRFUL DROCM DRSTM DU5 EBD EBS ECGQY EJD EMOBN F00 F01 F04 F5P FBQ FEDTE G-S G.N GNP GODZA H.T H.X HF~ HHY HHZ HVGLF HZ~ IX1 J0M JPC KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M64 MEWTI MK4 MRFUL MRSTM MSFUL MSSTM MXFUL MXSTM N04 N05 N9A NF~ O66 O9- P2P P2W P2X P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RWI RX1 RYL SAMSI SUPJJ SV3 UB1 V2E V8K W8V W99 WBFHL WBKPD WIB WIH WIK WJL WOHZO WQJ WRC WWF WXSBR WYISQ XG1 XV2 Y6R ZZTAW ~IA ~WT AHBTC BSCLL AAHBH AITYG HGLYW OIG CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c4743-f03ea94bd13d0b6fcf992120f3f34b5254ac5f23ca0c1f42bdf933f29845e6fd3 |
IEDL.DBID | DR2 |
ISSN | 0958-0344 |
IngestDate | Sat Aug 17 00:27:57 EDT 2024 Fri Aug 23 00:52:04 EDT 2024 Sat Sep 28 07:38:28 EDT 2024 Sat Aug 24 00:45:31 EDT 2024 Wed Jan 17 05:00:28 EST 2024 Wed Dec 27 19:07:15 EST 2023 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 1 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c4743-f03ea94bd13d0b6fcf992120f3f34b5254ac5f23ca0c1f42bdf933f29845e6fd3 |
Notes | istex:B41F2FD516A34E1CDCBAD75A5961FB7F7D5A1F94 ark:/67375/WNG-MQHBXR6Z-D ArticleID:PCA673 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pca.673 |
PMID | 12597251 |
PQID | 73046642 |
PQPubID | 23479 |
PageCount | 10 |
ParticipantIDs | proquest_miscellaneous_73046642 crossref_primary_10_1002_pca_673 pubmed_primary_12597251 wiley_primary_10_1002_pca_673_PCA673 istex_primary_ark_67375_WNG_MQHBXR6Z_D fao_agris_US201301028376 |
PublicationCentury | 2000 |
PublicationDate | 2003 2003-01 January/February 2003 2003 Jan-Feb 2003-01-00 20030101 |
PublicationDateYYYYMMDD | 2003-01-01 |
PublicationDate_xml | – year: 2003 text: 2003 |
PublicationDecade | 2000 |
PublicationPlace | Chichester, UK |
PublicationPlace_xml | – name: Chichester, UK – name: England |
PublicationTitle | Phytochemical analysis |
PublicationTitleAlternate | Phytochem. Anal |
PublicationYear | 2003 |
Publisher | John Wiley & Sons, Ltd |
Publisher_xml | – name: John Wiley & Sons, Ltd |
References | Egan RS, Stanaszek RS and Williamson DE. 1973. Solution conformation of (+)-tubocurarine chloride. J Chem Soc Perkin Trans II 716-717. Guha KP, Mukherjee B and Mukherjee R. 1979. Bisbenzylisoquinoline alkaloids. Reviews. J Nat Prod 42: 1-85 [and references therein]. Koike L, Marsaioli AJ and Reis F de AM. 1981. Proton and carbon-13 nuclear magnetic resonance spectroscopy and conformational aspects of the curine class of bisbenzylisoquinoline alkaloids. J Org Chem 46: 2385-2389. Berthou S, Jossang A, Guinaudeau H, Leboeuf M and Cavé A. 1988. Alcaloïdes bisbenzylisoquinoleiques biphenyliques de Guatteria guainensis. Tetrahedron 44: 1293-2201. Kanyinda B, Vanhaelen-Fastré R and Vanhaelen M. 1996. Two new seco-bisbenzylisoquinoline alkaloids from the leaves of Anisocycla jollyana. J Nat Prod 59: 498-500. Saa JM, Lakshimikantham MV, Mitchell MJ and Cava MP. 1976. Thalibrunimine, a new iminobisbenzylisoquinoline alkaloid; conformers of thalsimine. Tetrahedron Lett 7: 513-516. Koike L, Marsaioli AJ, Rúveda EA and Reis F de AM. 1979. Stereochemical aspects and 13C-NMR spectroscopy of the berbamine class of bisbenzylisoquinoline alkaloids. Tetrahedron Lett 39: 3765-3768. Wang XK, Zhao TF, Lai S, Shizuri Y and Yamamura S. 1993. Three cissampareine-type bisbenzylisoquinoline alkaloids from Cyclea species. Phytochemistry 33: 5, 1249-1252. Kanyinda B, Vanhaelen-Fastré R and Vanhaelen M. 1997. Two new isochondodendrine-type alkaloids from the root of Anisocycla jollyana. J Nat Prod 60: 1121-1124. Sun SW and Wu AC. 1998. Optimisation of the capillary electrophoretic separation of bisbenzylisoquinoline alkaloids by an overlapping resolution mapping scheme. J Chromatogr A 814: 223-231. Schiff PL. 1997. Bisbenzylisoquinoline alkaloids. Reviews. J Nat Prod 60: 934-953 [and references therein]. Bhakuni SD, Satish S and Dhar MM. 1972. Absolute configuration of isococlaurine. Tetrahedron 28: 1093-1095. Hall AM and Chang CJ. 1997. Multi-drug-resistance modulators from Stephania japonica. J Nat Prod 60: 1193-1195. Bick IRC and Clezy PS. 1953. The cleavage of biscoclaurine alkaloids with sodium in liquid ammonia. Part I. Curine and chondrocurine. J Chem Soc 3893-3896. Galinis DL, Wiemer DF and Cazin J. 1993. Cissampentin: a new bisbenzylisoquinoline alkaloid from Cissampelos fasciculata. Tetrahedron 49: 7, 1337-1342. King H. 1940. Curare alkaloids. Part V. Alkaloids from Chondrodendron species and the origin of radix pareirae bravae. J Chem Soc 737-746. Yang TH and Chen CM. 1970. Alkaloids of Nelumbo nucifera. J Chin Chem Soc 17: 4, 235-242 [Chem Abs 1971, 74: 100254g]. Cava MP, Kunitomo J and DaRocha AI. 1969. The alkaloids of Chondrodendron toxicoferum. Phytochemistry 8: 2341-2343. Schiff PL. 1991. Bisbenzylisoquinoline alkaloids. J Nat Prod 54: 645-749 [and references therein]. Sun SW, Kuo CH, Lee SS and Chen CK. 2000. Determination of bisbenzylisoquinoline alkaloids by high-performance liquid chromatography (II). J Chromatogr A 891: 189-194. Bhatnagar AK and Polpi SP. 1966. Chemical examination of the roots of Cissampelos pareira Linn. Part V. Structure and stereochemistry of Hayatidin. Experientia 23: 4, 242-243. Tomita M and Yamaguchi H. 1952. Alkaloids of menispermaceous plants. XCVI. Syntheses of coclaurine and analogous compounds. 4. Synthesis of dl-isococlaurine. J Pharm Soc Japan 72: 1219-1222. Ndaya Tshibangu JN, Chifundera K, Kaminsky R, Wright AD and König GM. 2002. Screening of African medicinal plants for anti-microbial and enzyme inhibitory activity. J Ethnopharmac 80: 25-35. Tomita M, Furukawa H, Yang TH and Lin TJ. 1964. Studies on the alkaloids of loti embryo (1). Structure of isoliensinine. Tetrahedron Lett 37: 2637-2642. Desjardins RE, Canfield CJ, Haynes DM and Chulay JD. 1979. Quantitative assessment of anti-malarial activity in vitro by a semi-automated microdilution technique. Antimicrob Agents Chemother 16: 710-718. Mambu L, Martin MT, Razafimahefa D, Ramanitrahasimbola D, Rasoanaivo P and Frappier F. 2000. Spectral characterisation and anti-plasmodial activity of bisbenzylisoquinolines from Isolona ghesquiereina. Planta Med 66: 537-540. Schiff PL. 1987. Bisbenzylisoquinoline alkaloids. J Nat Prod 50: 529-599 [and references therein]. Sun SW, Lee SS, Wu AC and Chen CK. 1998. Determination of bisbenzylisoquinoline alkaloids by high-performance liquid chromatography. J Chromatogr A 799: 337-342. Chowdhury AP and Roy R. 1972. Chemical investigations on Cissampelos pareira Linn. Sci Cult 38: 358-359. Jossang A, Cavé A, Saez J, Bartoli MH, Cavé A and Jossang P. 1996. Two highly populated conformations at room temperature of monterine and granjine, anti-tumour bisbenzylisoquinoline alkaloids: origin and three dimensional structures. J Org Chem 61: 3023-3030. Bhattacharji S, Roy AC and Dhar ML. 1962. Isolation and structure of hayatidin. J Sci Ind Res 21 B: 428-433. Haynes LJ, Herbert EJ and Plimmer JR. 1966. (++)-4″-O-methylcurine from Cissampelos pareira L. J Chem Soc 615-617. Ridley GR, Hofheinz W, Matile H, Jaquet C, Dorn A, Masciadri R, Jolidon S, Richter WF, Guenzi A, Girometta MA, Urwyler H, Huber W, Thaithong S and Peters W. 1996. 4-Aminoquinoline analogues of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum. Antimicrob Agents Chemother 40: 1846-1854. Schiff PL. 1983. Bisbenzylisoquinoline alkaloids. J Nat Prod 46: 1-43 [and references therein]. Wagner H, Bladt S and Zgainski EM. 1983. Drogenanalyse. Springer: Berlin. Telezhenetskaya MV and Yunusov SY. 1965. Structure of thalmine and thalmidine. Dokl Akad Nauk SSSR 162: 254 [Chem Abs 63: 5689]. Hultin E. 1961. Bisbenzylisoquinoline alkaloids. II. Methods for preparing the two monomethyl ethers of d-chondrocurine. Acta Chem Scand 15: 5, 1130-1140. Saez J, Fernandez E, Jossang A, Cavé A and Cavé A. 1988. Nouveaux alcaloïdes bisbenzylisoquinoléiques biphényliques de Crematosperma sp. Can J Chem 67: 275-278. Lemli J, Galeffi C, Messana I, Nicoletti M and Marini-Bettolo GB. 1985. A new bisbenzylisoquinoline alkaloid from a Peruvian curare. Planta Med 51: 68-69. Menachery MD, Stern EW, Steinbeiser RJ, Freyer AJ and Killmer LB. 2000. Cavanine, a novel α-hydroxybisbenzylisoquinoline alkaloid from Sciadotenia toxifera (Krukoff and A.C. Smith). Tetrahedron Lett 41: 2843-2846. Bick IRC, Harley-Mason J, Sheppard N and Vernengo MJ. 1961. Structural correlations in the nuclear magnetic resonance spectra of bisbenzylisoquinoline and aporphine alkaloids. J Chem Soc 1896-1903. Latscha HP and Klein HA. 1993. Organische Chemie- Basiswissen II, 3rd ed. Springer: Berlin; 52. Everett AJ, Lowe LA and Wilkinson S. 1970. Revision of the structures of (+)-tubocurine chloride and (+)-chondrocurine. Chem Commun 1020-1021. 1979; 39 1979; 16 1997; 60 1993; 49 1987; 50 1991; 54 1952; 72 2000; 66 1965; 162 2000; 41 1953 1981; 46 1998; 814 1973 1993 2000; 891 1970 1998; 799 2002 2002; 80 1996; 59 1970; 17 1961; 15 1972; 28 1976; 7 1969; 8 1993; 33 1996; 61 1988; 44 1988; 67 1962 1940 1996; 40 1961 1985; 51 1983 1964; 37 1966; 23 1979; 42 1983; 46 1972; 38 1966 Chowdhury AP (e_1_2_1_9_1) 1972; 38 Haynes LJ (e_1_2_1_16_1) 1966 Ridley GR (e_1_2_1_30_1) 1996; 40 e_1_2_1_42_1 e_1_2_1_20_1 e_1_2_1_41_1 Wang XK (e_1_2_1_44_1) 1993; 33 e_1_2_1_23_1 e_1_2_1_24_1 e_1_2_1_45_1 Bhattacharji S (e_1_2_1_5_1) 1962 e_1_2_1_21_1 e_1_2_1_22_1 e_1_2_1_43_1 e_1_2_1_27_1 e_1_2_1_28_1 e_1_2_1_25_1 e_1_2_1_26_1 Bhatnagar AK (e_1_2_1_4_1) 1966; 23 e_1_2_1_29_1 Telezhenetskaya MV (e_1_2_1_40_1) 1965; 162 e_1_2_1_7_1 e_1_2_1_31_1 e_1_2_1_8_1 e_1_2_1_6_1 e_1_2_1_3_1 e_1_2_1_12_1 e_1_2_1_35_1 e_1_2_1_13_1 e_1_2_1_34_1 e_1_2_1_10_1 e_1_2_1_33_1 e_1_2_1_2_1 e_1_2_1_11_1 e_1_2_1_32_1 e_1_2_1_39_1 e_1_2_1_17_1 e_1_2_1_38_1 e_1_2_1_14_1 e_1_2_1_37_1 e_1_2_1_15_1 e_1_2_1_36_1 e_1_2_1_18_1 e_1_2_1_19_1 |
References_xml | – volume: 59 start-page: 498 year: 1996 end-page: 500 article-title: Two new seco‐bisbenzylisoquinoline alkaloids from the leaves of publication-title: J Nat Prod – volume: 41 start-page: 2843 year: 2000 end-page: 2846 article-title: Cavanine, a novel α‐hydroxybisbenzylisoquinoline alkaloid from (Krukoff and A.C. Smith) publication-title: Tetrahedron Lett – year: 1983 – volume: 49 start-page: 7 year: 1993 end-page: 1342 article-title: Cissampentin: a new bisbenzylisoquinoline alkaloid from publication-title: Tetrahedron – volume: 40 start-page: 1846 year: 1996 end-page: 1854 article-title: 4‐Aminoquinoline analogues of chloroquine with shortened side chains retain activity against chloroquine‐resistant publication-title: Antimicrob Agents Chemother – volume: 23 start-page: 4 year: 1966 end-page: 243 article-title: Chemical examination of the roots of Linn. Part V. Structure and stereochemistry of Hayatidin publication-title: Experientia – start-page: 737 year: 1940 end-page: 746 article-title: Curare alkaloids. Part V. Alkaloids from species and the origin of radix pareirae bravae publication-title: J Chem Soc – start-page: 1896 year: 1961 end-page: 1903 article-title: Structural correlations in the nuclear magnetic resonance spectra of bisbenzylisoquinoline and aporphine alkaloids publication-title: J Chem Soc – volume: 17 start-page: 4 year: 1970 end-page: 242 article-title: Alkaloids of publication-title: J Chin Chem Soc – start-page: 1020 year: 1970 end-page: 1021 article-title: Revision of the structures of (+)‐tubocurine chloride and (+)‐chondrocurine publication-title: Chem Commun – volume: 28 start-page: 1093 year: 1972 end-page: 1095 article-title: Absolute configuration of isococlaurine publication-title: Tetrahedron – volume: 33 start-page: 5 year: 1993 end-page: 1252 article-title: Three cissampareine‐type bisbenzylisoquinoline alkaloids from species publication-title: Phytochemistry – volume: 38 start-page: 358 year: 1972 end-page: 359 article-title: Chemical investigations on Linn publication-title: Sci Cult – volume: 54 start-page: 645 year: 1991 end-page: 749 article-title: Bisbenzylisoquinoline alkaloids publication-title: J Nat Prod – volume: 72 start-page: 1219 year: 1952 end-page: 1222 article-title: Alkaloids of menispermaceous plants. XCVI. Syntheses of coclaurine and analogous compounds. 4. Synthesis of dl‐isococlaurine publication-title: J Pharm Soc Japan – start-page: 52 year: 1993 – volume: 891 start-page: 189 year: 2000 end-page: 194 article-title: Determination of bisbenzylisoquinoline alkaloids by high‐performance liquid chromatography (II) publication-title: J Chromatogr A – volume: 51 start-page: 68 year: 1985 end-page: 69 article-title: A new bisbenzylisoquinoline alkaloid from a Peruvian curare publication-title: Planta Med – volume: 162 start-page: 254 year: 1965 article-title: Structure of thalmine and thalmidine publication-title: Dokl Akad Nauk SSSR – volume: 44 start-page: 1293 year: 1988 end-page: 2201 article-title: Alcaloïdes bisbenzylisoquinoleiques biphenyliques de publication-title: Tetrahedron – volume: 42 start-page: 1 year: 1979 end-page: 85 article-title: Bisbenzylisoquinoline alkaloids. Reviews publication-title: J Nat Prod – start-page: 615 year: 1966 end-page: 617 article-title: (++)‐4″‐O‐methylcurine from L publication-title: J Chem Soc – volume: 61 start-page: 3023 year: 1996 end-page: 3030 article-title: Two highly populated conformations at room temperature of monterine and granjine, anti‐tumour bisbenzylisoquinoline alkaloids: origin and three dimensional structures publication-title: J Org Chem – volume: 39 start-page: 3765 year: 1979 end-page: 3768 article-title: Stereochemical aspects and C‐NMR spectroscopy of the berbamine class of bisbenzylisoquinoline alkaloids publication-title: Tetrahedron Lett – volume: 80 start-page: 25 year: 2002 end-page: 35 article-title: Screening of African medicinal plants for anti‐microbial and enzyme inhibitory activity publication-title: J Ethnopharmac – volume: 7 start-page: 513 year: 1976 end-page: 516 article-title: Thalibrunimine, a new iminobisbenzylisoquinoline alkaloid; conformers of thalsimine publication-title: Tetrahedron Lett – start-page: 428 year: 1962 end-page: 433 article-title: Isolation and structure of hayatidin publication-title: J Sci Ind Res – volume: 60 start-page: 934 year: 1997 end-page: 953 article-title: Bisbenzylisoquinoline alkaloids. Reviews publication-title: J Nat Prod – volume: 46 start-page: 2385 year: 1981 end-page: 2389 article-title: Proton and carbon‐13 nuclear magnetic resonance spectroscopy and conformational aspects of the curine class of bisbenzylisoquinoline alkaloids publication-title: J Org Chem – volume: 50 start-page: 529 year: 1987 end-page: 599 article-title: Bisbenzylisoquinoline alkaloids publication-title: J Nat Prod – volume: 66 start-page: 537 year: 2000 end-page: 540 article-title: Spectral characterisation and anti‐plasmodial activity of bisbenzylisoquinolines from publication-title: Planta Med – volume: 8 start-page: 2341 year: 1969 end-page: 2343 article-title: The alkaloids of publication-title: Phytochemistry – volume: 60 start-page: 1121 year: 1997 end-page: 1124 article-title: Two new isochondodendrine‐type alkaloids from the root of publication-title: J Nat Prod – year: 2002 – volume: 67 start-page: 275 year: 1988 end-page: 278 article-title: Nouveaux alcaloïdes bisbenzylisoquinoléiques biphényliques de sp publication-title: Can J Chem – volume: 814 start-page: 223 year: 1998 end-page: 231 article-title: Optimisation of the capillary electrophoretic separation of bisbenzylisoquinoline alkaloids by an overlapping resolution mapping scheme publication-title: J Chromatogr A – volume: 16 start-page: 710 year: 1979 end-page: 718 article-title: Quantitative assessment of anti‐malarial activity by a semi‐automated microdilution technique publication-title: Antimicrob Agents Chemother – volume: 46 start-page: 1 year: 1983 end-page: 43 article-title: Bisbenzylisoquinoline alkaloids publication-title: J Nat Prod – volume: 37 start-page: 2637 year: 1964 end-page: 2642 article-title: Studies on the alkaloids of loti embryo (1). Structure of isoliensinine publication-title: Tetrahedron Lett – start-page: 716 year: 1973 end-page: 717 article-title: Solution conformation of (+)‐tubocurarine chloride publication-title: J Chem Soc Perkin Trans II – volume: 15 start-page: 5 year: 1961 end-page: 1140 article-title: Bisbenzylisoquinoline alkaloids. II. Methods for preparing the two monomethyl ethers of ‐chondrocurine publication-title: Acta Chem Scand – start-page: 3893 year: 1953 end-page: 3896 article-title: The cleavage of biscoclaurine alkaloids with sodium in liquid ammonia. Part I. Curine and chondrocurine publication-title: J Chem Soc – volume: 799 start-page: 337 year: 1998 end-page: 342 article-title: Determination of bisbenzylisoquinoline alkaloids by high‐performance liquid chromatography publication-title: J Chromatogr A – volume: 60 start-page: 1193 year: 1997 end-page: 1195 article-title: Multi‐drug‐resistance modulators from publication-title: J Nat Prod – ident: e_1_2_1_7_1 doi: 10.1039/jr9610001896 – ident: e_1_2_1_8_1 doi: 10.1016/S0031-9422(00)88152-2 – ident: e_1_2_1_32_1 doi: 10.1139/v89-045 – ident: e_1_2_1_6_1 doi: 10.1039/jr9530003893 – ident: e_1_2_1_21_1 doi: 10.1039/JR9400000737 – ident: e_1_2_1_41_1 doi: 10.1248/yakushi1947.72.10_1219 – ident: e_1_2_1_23_1 doi: 10.1021/jo00324a036 – ident: e_1_2_1_45_1 doi: 10.1002/jccs.197000030 – ident: e_1_2_1_43_1 doi: 10.1007/978-3-642-68773-0 – ident: e_1_2_1_22_1 doi: 10.1016/S0040-4039(01)95519-4 – ident: e_1_2_1_18_1 doi: 10.1021/jo950767n – ident: e_1_2_1_34_1 doi: 10.1021/np50052a001 – ident: e_1_2_1_14_1 doi: 10.1021/np50001a001 – start-page: 615 year: 1966 ident: e_1_2_1_16_1 article-title: (++)‐4″‐O‐methylcurine from Cissampelos pareira L publication-title: J Chem Soc contributor: fullname: Haynes LJ – volume: 162 start-page: 254 year: 1965 ident: e_1_2_1_40_1 article-title: Structure of thalmine and thalmidine publication-title: Dokl Akad Nauk SSSR contributor: fullname: Telezhenetskaya MV – ident: e_1_2_1_13_1 doi: 10.1016/S0040-4020(01)90186-3 – volume: 23 start-page: 4 year: 1966 ident: e_1_2_1_4_1 article-title: Chemical examination of the roots of Cissampelos pareira Linn. Part V. Structure and stereochemistry of Hayatidin publication-title: Experientia contributor: fullname: Bhatnagar AK – ident: e_1_2_1_31_1 doi: 10.1016/S0040-4039(00)77898-1 – ident: e_1_2_1_38_1 doi: 10.1016/S0021-9673(97)01065-0 – ident: e_1_2_1_12_1 doi: 10.1039/c29700001020 – ident: e_1_2_1_3_1 doi: 10.1016/0040-4020(72)80168-6 – ident: e_1_2_1_42_1 doi: 10.1016/S0040-4039(00)70400-X – ident: e_1_2_1_2_1 doi: 10.1016/S0040-4020(01)81727-0 – ident: e_1_2_1_20_1 doi: 10.1021/np970257j – ident: e_1_2_1_24_1 doi: 10.1007/978-3-662-09141-8 – ident: e_1_2_1_37_1 doi: 10.1016/S0021-9673(98)00416-6 – ident: e_1_2_1_15_1 doi: 10.1021/np9702042 – ident: e_1_2_1_26_1 doi: 10.1055/s-2000-8610 – ident: e_1_2_1_10_1 doi: 10.1128/AAC.16.6.710 – volume: 38 start-page: 358 year: 1972 ident: e_1_2_1_9_1 article-title: Chemical investigations on Cissampelos pareira Linn publication-title: Sci Cult contributor: fullname: Chowdhury AP – ident: e_1_2_1_33_1 doi: 10.1021/np50025a001 – ident: e_1_2_1_39_1 doi: 10.1016/S0021-9673(00)00629-4 – volume: 40 start-page: 1846 year: 1996 ident: e_1_2_1_30_1 article-title: 4‐Aminoquinoline analogues of chloroquine with shortened side chains retain activity against chloroquine‐resistant Plasmodium falciparum publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.40.8.1846 contributor: fullname: Ridley GR – ident: e_1_2_1_35_1 doi: 10.1021/np50075a001 – ident: e_1_2_1_25_1 doi: 10.1055/s-2007-969398 – ident: e_1_2_1_36_1 doi: 10.1021/np9700174 – ident: e_1_2_1_17_1 doi: 10.3891/acta.chem.scand.15-1130 – start-page: 428 year: 1962 ident: e_1_2_1_5_1 article-title: Isolation and structure of hayatidin publication-title: J Sci Ind Res contributor: fullname: Bhattacharji S – ident: e_1_2_1_11_1 doi: 10.1039/p29730000716 – ident: e_1_2_1_29_1 doi: 10.1016/S0378-8741(01)00409-3 – volume: 33 start-page: 5 year: 1993 ident: e_1_2_1_44_1 article-title: Three cissampareine‐type bisbenzylisoquinoline alkaloids from Cyclea species publication-title: Phytochemistry contributor: fullname: Wang XK – ident: e_1_2_1_19_1 doi: 10.1021/np9602527 – ident: e_1_2_1_27_1 doi: 10.1016/S0040-4039(00)00299-9 – ident: e_1_2_1_28_1 |
SSID | ssj0009996 |
Score | 1.7760592 |
Snippet | The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable... Abstract The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum . In order... |
SourceID | proquest crossref pubmed wiley istex fao |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 13 |
SubjectTerms | alkaloids Alkaloids - isolation & purification Alkaloids - pharmacology Animals anti-malarial anti-plasmodial antimalarials Antimalarials - isolation & purification Antimalarials - pharmacology Benzylisoquinolines bisbenzylisoquinoline alkaloids bisbenzylisoquinone alkaloids cell lines Cells, Cultured chemical analysis chemical structure Chromatography, High Pressure Liquid Cissampelos Cissampelos - chemistry Cissampelos mucronata cytotoxicity gas chromatography high performance liquid chromatography HPLC humans isolation Isoquinolines - isolation & purification Isoquinolines - pharmacology Magnoliaceae mass spectrometry medicinal plants Molecular Structure natural product isolation phytochemicals plant extracts Plant Roots - chemistry Plasmodium falciparum Plasmodium falciparum - drug effects qualitative analysis quantitative analysis roots Schisandra chinensis spectral analysis volatile compounds |
Title | HPLC isolation of the anti-plasmodially active bisbenzylisoquinone alkaloids present in roots of Cissampelos mucronata |
URI | https://api.istex.fr/ark:/67375/WNG-MQHBXR6Z-D/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fpca.673 https://www.ncbi.nlm.nih.gov/pubmed/12597251 https://search.proquest.com/docview/73046642 |
Volume | 14 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5BhQQXHgXa8PSh4rZtGuexObaBskK0KoUVq14s24lRtGmyNInU7YmfwG_klzBj73YpAglxyiUTTWbG9jcez2eArcDkXOpUDnKT-4OQoy9kHtMG_DD2pdE8sez6h0fxaBy-m0STX676cvwQVxtuNDLsfE0DXKp2Z0UaOsOMP06I55No9AgOnayIowjGO5Y9aiALQ9cuS5I7C7lr69BNIxtEp2TYiz9BzevI1S49B_fgdKm0O3Ey3e47ta0vf-Nz_K-_ug93F4CU7bkIegA3inodbu03CBrn63A7W14I9xAuRsfvM1ZisFpvssYwRI8MXVP--PZ9hjD8rKE2lGrOpJ1FmaJiR305r1Doa1_WTY2vV1NZNWXespnrfGJlzRC-dy19MMM4kIjkq6ZlZz2arpadfATjgzefstFgcXHDQIdEeWp8Xsg0VPkuz33qJjJpikukb7jhoYowJ5U6MgHX0te7JgxUblLOTZAOw6iIMXoewxqptAlMpUYhaB1KhZkf11rFPFBcaWqITYzRHrClG8XM8XMIx8QcCLQlHVvzYBPdK-QXnDXF-GNAtVoLq5LYg1fW51ei8nxKIkkkPh-9FYcfRvuTk_hUvPbg5TIoBFqdiiqyLpq-FQmVljGJ82DDxcpKDcwsE4SPHmxZj_9NP3Gc7eHjyb-99hTu2POEdhfoGax1533xHHFRp17YIfATNS4LQA |
link.rule.ids | 315,786,790,1382,4043,27954,27955,27956,46327,46751 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB7RglQuBcqj5tU9VNzSul4_4mPrUgwkUSmNiMphtbv2VlZcOzSJ1PTET-A38kuYWSeNikBCnHzZscY7M7vfzO58Btj2TMaljmUrM5nb8jnaQmYhFeDboSuN5pFl1-_2wrTvfxgEg_mtSuqFafghbgpuFBl2vaYAp4L07pI1dIQpfxjxFbiLwR5QUB6eLKmjCMg3PHvUQub7TcMsie7OBW_tRCtG1ohPaWqv_gQ2b2NXu_kcPYCvC7WbOyfDnelE7ejr3xgd_--7HsL6HJOy_caJHsGdvNqAewc14sbZBqwli3_CPYar9LiTsAL91RqU1YYhgGRoneLn9x8jROIXNXWilDMm7ULKFJ13VNezEoW-TYuqrnB4OZRlXWRjNmqan1hRMUTwkzG9MEFXkAjmy3rMLqY4d5WcyCfQP3p7mqSt-b8bWton1lPj8lzGvsr2eOZSQ5GJY9wlXcMN91WAaanUgfG4lq7eM76nMhNzbry47Qd5iA70FFZJpU1gKjYKcWtbKkz-uNYq5J7iSlNPbGSMdoAt7ChGDUWHaMiYPYFzSTfXHNhE-wp5jgun6H_26LjWIqsodOCNNfqNqLwckkgUiC-9d6L7KT0YnIRn4tCBrYVXCJx1OleRVV5PxyKi02XM4xx41jjLUg1MLiNEkA5sW5P_TT9xnOzj4_m_DduCtfS02xGd972PL-C-vV5oi0IvYXVyOc1fIUyaqNc2Hn4B3o0PYA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwEB7RgoALP6XQ8FcfKm7bprGTbI5tlmWBdrUUVqx6sWwnRtGmSegmUrcnHoFn5EkYO7tdikBCnHLJRJOZsf2Nx_MZYMfTCRUqEp1EJ26HUfSFSAKzAd8NXKEVDS27_vEwGIzZu4k_-eWqr5Yf4mrDzYwMO1-bAV4lem9FGlphxh-EdA1usoB6Ju_qnayYowyOb2n2TAcZY22_rBHdWwheW4jWtCgRnhrLXvwJa16Hrnbt6d-H06XW7ZGT6W5Ty111-Ruh43_91gO4t0Ck5KANoYdwIy024NZhiahxvgF34uWNcI_gYjA6ikmG0WrdSUpNED4S9E3249v3CnH4WWn6UPI5EXYaJdJUO4rLeY5CX5usKAt8PZ-KvMySGana1ieSFQTxez0zH4wxEARC-byckbMGTVeIWmzCuP_6UzzoLG5u6ChmOE-1S1MRMZns08Q17UQ6inCNdDXVlEkfk1KhfO1RJVy1r5knEx1Rqr2oy_w0wPB5DOtGpS0gMtISUWtXSEz9qFISnS2pVKYjNtRaOUCWbuRVS9DBWypmj6Mtzbk1B7bQvVx8wWmTjz96plhrcVUYOPDK-vxKVJxPjUjo88_DN_z4w-BwchKc8p4D28ug4Gh1U1URRVo2Mx6a2jJmcQ48aWNlpQamliHiRwd2rMf_ph8fxQf4ePpvr23D7VGvz4_eDt8_g7v2bKHdEXoO6_V5k75AjFTLl3Y0_ASxdQ4P |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=HPLC+isolation+of+the+anti-plasmodially+active+bisbenzylisoquinone+alkaloids+present+in+roots+of+Cissampelos+mucronata&rft.jtitle=Phytochemical+analysis&rft.au=Tshibangu%2C+J.N&rft.au=Wright%2C+A.D&rft.au=Konig%2C+G.M&rft.date=2003&rft.issn=0958-0344&rft.eissn=1099-1565&rft.volume=14&rft.issue=1&rft.spage=13&rft.epage=22&rft_id=info:doi/10.1002%2Fpca.673&rft.externalDocID=US201301028376 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0958-0344&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0958-0344&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0958-0344&client=summon |