HPLC isolation of the anti-plasmodially active bisbenzylisoquinone alkaloids present in roots of Cissampelos mucronata

The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationar...

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Published inPhytochemical analysis Vol. 14; no. 1; pp. 13 - 22
Main Authors Tshibangu, J.N, Wright, A.D, Konig, G.M
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 2003
Subjects
alkaloids
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
anti-malarial
anti-plasmodial
antimalarials
Antimalarials - isolation & purification
Antimalarials - pharmacology
Benzylisoquinolines
bisbenzylisoquinoline alkaloids
bisbenzylisoquinone alkaloids
cell lines
Cells, Cultured
chemical analysis
chemical structure
Chromatography, High Pressure Liquid
Cissampelos
Cissampelos - chemistry
Cissampelos mucronata
cytotoxicity
gas chromatography
high performance liquid chromatography
HPLC
humans
isolation
Isoquinolines - isolation & purification
Isoquinolines - pharmacology
Magnoliaceae
mass spectrometry
medicinal plants
Molecular Structure
natural product isolation
phytochemicals
plant extracts
Plant Roots - chemistry
Plasmodium falciparum
Plasmodium falciparum - drug effects
qualitative analysis
quantitative analysis
roots
Schisandra chinensis
spectral analysis
volatile compounds
China
Republic of the Congo
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Abstract The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationary and mobile phases. The active principles were determined to be a series of bisbenzylisoquinoline alkaloids, a group of natural products for which one of the first routine preparative HPLC separation methods is described. Copyright © 2003 John Wiley & Sons, Ltd.
AbstractList The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationary and mobile phases. The active principles were determined to be a series of bisbenzylisoquinoline alkaloids, a group of natural products for which one of the first routine preparative HPLC separation methods is described.
Abstract The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum . In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationary and mobile phases. The active principles were determined to be a series of bisbenzylisoquinoline alkaloids, a group of natural products for which one of the first routine preparative HPLC separation methods is described. Copyright © 2003 John Wiley & Sons, Ltd.
The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationary and mobile phases. The active principles were determined to be a series of bisbenzylisoquinoline alkaloids, a group of natural products for which one of the first routine preparative HPLC separation methods is described. Copyright © 2003 John Wiley & Sons, Ltd.
Author König, Gabriele M.
Wright, Anthony D.
Tshibangu, Jeannette Ndaya
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Snippet The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable...
Abstract The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum . In order...
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SubjectTerms alkaloids
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
anti-malarial
anti-plasmodial
antimalarials
Antimalarials - isolation & purification
Antimalarials - pharmacology
Benzylisoquinolines
bisbenzylisoquinoline alkaloids
bisbenzylisoquinone alkaloids
cell lines
Cells, Cultured
chemical analysis
chemical structure
Chromatography, High Pressure Liquid
Cissampelos
Cissampelos - chemistry
Cissampelos mucronata
cytotoxicity
gas chromatography
high performance liquid chromatography
HPLC
humans
isolation
Isoquinolines - isolation & purification
Isoquinolines - pharmacology
Magnoliaceae
mass spectrometry
medicinal plants
Molecular Structure
natural product isolation
phytochemicals
plant extracts
Plant Roots - chemistry
Plasmodium falciparum
Plasmodium falciparum - drug effects
qualitative analysis
quantitative analysis
roots
Schisandra chinensis
spectral analysis
volatile compounds
Title HPLC isolation of the anti-plasmodially active bisbenzylisoquinone alkaloids present in roots of Cissampelos mucronata
URI https://api.istex.fr/ark:/67375/WNG-MQHBXR6Z-D/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fpca.673
https://www.ncbi.nlm.nih.gov/pubmed/12597251
https://search.proquest.com/docview/73046642
Volume 14
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