HPLC isolation of the anti-plasmodially active bisbenzylisoquinone alkaloids present in roots of Cissampelos mucronata
The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationar...
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Published in | Phytochemical analysis Vol. 14; no. 1; pp. 13 - 22 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
2003
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Subjects | |
Online Access | Get full text |
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Summary: | The methanolic extract of dried, powdered Cissampelos mucronata roots possesses significant in vitro activity against Plasmodium falciparum. In order to enable further pharmacological testing, the substances responsible for the observed activity were purified, mainly by HPLC, using various stationary and mobile phases. The active principles were determined to be a series of bisbenzylisoquinoline alkaloids, a group of natural products for which one of the first routine preparative HPLC separation methods is described. Copyright © 2003 John Wiley & Sons, Ltd. |
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Bibliography: | istex:B41F2FD516A34E1CDCBAD75A5961FB7F7D5A1F94 ark:/67375/WNG-MQHBXR6Z-D ArticleID:PCA673 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0958-0344 1099-1565 |
DOI: | 10.1002/pca.673 |