Biologically active quinoline and quinazoline alkaloids part II

• Published in: Medicinal research reviews Vol. 38; no. 5; pp. 1614 - 1660
• Main Authors: Shang, Xiao‐Fei, Morris‐Natschke, Susan L., Yang, Guan‐Zhou, Liu, Ying‐Qian, Guo, Xiao, Xu, Xiao‐Shan, Goto, Masuo, Li, Jun‐Cai, Zhang, Ji‐Yu, Lee, Kuo‐Hsiung
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2018
• Subjects: Alkaloids - chemistry; Alkaloids - pharmacology; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Antioxidants - chemistry; Antioxidants - pharmacology; biological activities; Biological activity; camptothecin; Humans; natural products; Pharmacology; Protective Agents - chemistry; Protective Agents - pharmacology; quinazoline alkaloids; Quinazolines - chemistry; Quinazolines - pharmacology; quinoline alkaloids; Quinolines - chemistry; Quinolines - pharmacology; R&D; Research & development; quinoline alkaloids; natural products; biological activities; camptothecin; quinazoline alkaloids
• ISSN: 0198-6325; 1098-1128; 1098-1128
• DOI: 10.1002/med.21492

To follow‐up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009‒2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti‐inflammatory, hepatoprotective, antioxidant, anti‐asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.