Insulin‐like growth factor binding protein‐4: The quest for the breakthrough biomarker in pulmonary arterial hypertension

• Published in: Pulmonary circulation Vol. 13; no. 2; pp. e12252 - n/a
• Main Authors: Estrada, Rodolfo A., Sahay, Sandeep
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.04.2023; John Wiley and Sons Inc; Wiley
• Subjects: biomarker; Biomarkers; Cardiovascular disease; Growth factors; Hemodynamics; Insulin; Medical prognosis; Mortality; Patients; Proteins; Pulmonary arteries; Pulmonary hypertension; severity; survival; severity; biomarker; pulmonary hypertension; survival

Energy metabolism pathways and their association with cell proliferation and growth have been related to PAH, in particular the insulin-like growth factor (IGF) axis pathways. High-throughput plasma proteome analysis in PAH patients has identified proteins that correlate to survival, identifying the...