Insulin‐like growth factor binding protein‐4: The quest for the breakthrough biomarker in pulmonary arterial hypertension

Energy metabolism pathways and their association with cell proliferation and growth have been related to PAH, in particular the insulin-like growth factor (IGF) axis pathways. High-throughput plasma proteome analysis in PAH patients has identified proteins that correlate to survival, identifying the...

Full description

Saved in:
Bibliographic Details
Published inPulmonary circulation Vol. 13; no. 2; pp. e12252 - n/a
Main Authors Estrada, Rodolfo A., Sahay, Sandeep
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.04.2023
John Wiley and Sons Inc
Wiley
Subjects
biomarker
Biomarkers
Cardiovascular disease
Growth factors
Hemodynamics
Insulin
Medical prognosis
Mortality
Patients
Proteins
Pulmonary arteries
Pulmonary hypertension
severity
survival
severity
biomarker
pulmonary hypertension
survival
Online AccessGet full text

Cover

More Information
Summary:Energy metabolism pathways and their association with cell proliferation and growth have been related to PAH, in particular the insulin-like growth factor (IGF) axis pathways. High-throughput plasma proteome analysis in PAH patients has identified proteins that correlate to survival, identifying the insulin-growth factor binding protein-1 (IGFBP-1) as one of them. Subgroup analysis revealed that regardless of PAH subtype, above median IGFBP-4 levels were associated with worsening survival rates. Sandeep Sahay: Grants/Research Support: Research grant from United Therapeutics; Consultant: United Therapeutics, J&J, Bayer, Gossamer Bio, Liquidia technologies, Keros; Speaker's Bureau: Janssen, United Therapeutics (honorarium received by Houston Methodist Hospital Foundation); Clinical trial support from United Therapeutics, Janssen, Gossamer Bio, Altavant Sciences, Liquidia technologies, Novartis, Keros.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:2045-8940
2045-8932
2045-8940
DOI:10.1002/pul2.12252