Recent advances in the understanding and management of polycystic ovary syndrome [version 1; peer review: 3 approved]

Polycystic ovary syndrome (PCOS) is a multifaceted condition characterized by chronic anovulation and excess ovarian activity, in contrast to other causes of anovulation that involve ovarian dormancy or primary insufficiency. Recent studies indicated that PCOS is associated with low-grade chronic in...

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Bibliographic Details
Published inF1000 research Vol. 8; p. 565
Main Authors Rocha, Ana L, Oliveira, Flávia R, Azevedo, Rosana C, Silva, Virginia A, Peres, Thais M, Candido, Ana L, Gomes, Karina B, Reis, Fernando M
Format Journal Article
LanguageEnglish
Published England Faculty of 1000 Ltd 2019
F1000 Research Limited
F1000 Research Ltd
Subjects
Adipose tissue
Androgens
Aromatase
Cardiovascular disease
Citric acid
Clomiphene
Coexistence
Cytokines
Dormancy
Drug dosages
Fatty liver
Infertility
Insulin
Insulin resistance
Liver diseases
Menstruation
Metabolism
Obesity
Phenotypes
Polycystic ovary syndrome
Pregnancy
Reproductive health
Review
Systematic review
Testosterone
Womens health
Brazil
menstrual irregularity
PCOS
infertility
insulin resistance
polycystic ovary syndrome
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Summary:Polycystic ovary syndrome (PCOS) is a multifaceted condition characterized by chronic anovulation and excess ovarian activity, in contrast to other causes of anovulation that involve ovarian dormancy or primary insufficiency. Recent studies indicated that PCOS is associated with low-grade chronic inflammation and that women with PCOS are at increased risk of non-alcoholic fatty liver disease. The inflammatory and metabolic derangements associated with PCOS are explained in part by the coexistence of insulin resistance and obesity but are further fueled by the androgen excess. New insights into the regulation of hormones and cytokines in muscle and fat tissue support the concept that PCOS is a systemic syndrome. The therapeutic plan should be tailored to the patient phenotype, complaints, and reproductive desire. Of note, the aromatase inhibitor letrozole seems to be more effective than the reference drug clomiphene citrate to treat infertility due to PCOS. Integral management by a multidisciplinary team may help the patients to adhere to lifestyle interventions and thereby reduce body adiposity and recover their metabolic and reproductive health.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
No competing interests were disclosed.
ALR performed the bibliographic search and drafted the manuscript. FRO, RCA, VAS, and TMP assisted in the bibliographic search and in the preparation of text and figures. ALC and KBG evaluated the evidence and edited the manuscript for significant content. FMR conceived the review, evaluated the evidence, and corrected the manuscript. All authors were involved in the revision of the draft manuscript and have agreed to the final content.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.15318.1