Protective Effect of a New Monophenolic Antioxidant TS-13 in a Mouse Model of Parkinson’s Disease

• Published in: Bulletin of experimental biology and medicine Vol. 175; no. 2; pp. 265 - 269
• Main Authors: Menshchikova, E. B., Khrapova, M. V., Kozhin, P. M., Chechushkov, A. V., Serykh, A. E., Romakh, L. P., Kandalintseva, N. V.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2023; Springer; Springer Nature B.V
• Subjects: Analysis; Animals; Antioxidants; Anxiety; Behavior; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cellular biology; Clinical medicine; Correlation analysis; Drinking water; Experimental methods; Experimental Methods for Clinical Practice; Exploratory behavior; Free radicals; Inflammation; Internal Medicine; Laboratory Medicine; Locomotor activity; Medicine; Mice; Motor activity; Movement disorders; MPTP; Neurodegenerative diseases; Open-field behavior; Oxidative stress; Parkinson's disease; Pathology; Research centers; Research methodology; Theories of aging; aging; antioxidants; Keap1/Nrf2/ARE system; Parkinson’s disease; reactive oxygen species
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-023-05847-6

The development of means of the prevention and treatment of age-related neurodegenerative diseases, as well as geroprotectors, among other things, is based on the inflammatory and free radical theories of aging. In this context, we studied the effect of sodium monophenol 3-(3’- tert -butyl-4’-hydroxyphenyl)propyl thiosulfonate (TS-13) on the behavioral and locomotor activity of C57BL/6 mice in modeling Parkinson’s disease by MPTP neurotoxin injection. TS-13 administration significantly improved orientation and exploratory activity and emotional response of the animals in the open field test, but did not affect the increase in anxiety caused by MPTP injection. Long-term (6 months) TS-13 administration did not suppress spontaneous motor activity in BALB/c mice and slightly increased their exploratory activity.