Performance evaluation of collision–reaction interface and internal standardization in quadrupole ICP-MS measurements

• Published in: Talanta (Oxford) Vol. 86; pp. 241 - 247
• Main Authors: Salazar, Rodrigo F.S., Guerra, Marcelo B.B., Pereira-Filho, Edenir R., Nóbrega, Joaquim A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 30.10.2011; Elsevier
• Subjects: Analytical chemistry; Cadmium; Chemistry; Chromium; Collision–reaction interface (CRI); Cones; Exact sciences and technology; Internal standardization; Mass Spectrometry - methods; Mass Spectrometry - standards; Performance evaluation; Polyatomic ions; Quadrupoles; Reference Standards; Scandium; Spectrometric and optical methods; Spectrophotometry, Atomic - methods; Spectrophotometry, Atomic - standards; Standardization; Transport effects; Internal standardization; Collision–reaction interface (CRI); Polyatomic ions; Transport effects; Water; Performance evaluation; Internal standard; Standardization; Inductive coupling plasma spectrometry; Vinegar; Quadrupole spectrometer; Improvement; Accuracy; Collision-reaction interface (CRI); Molybdenum V; Coupled method; Device; Sample; Use; Foodstuff; Certified reference material; Antimony V; Trace element; Chromium V; Sampler; Reference material; Strategy; Mass spectrometry; Interface
• ISSN: 0039-9140; 1873-3573
• DOI: 10.1016/j.talanta.2011.09.009

► The combination of CRI-technology and internal standards for ICP-QMS is here discussed. ► Non-spectral and spectral interferences are minimized. ► Figures of merit are also improved. ► Analytical performance is shown for complex samples. The combined use of internal standardization with collision and reaction interface in an inductively coupled plasma quadrupole mass spectrometer (ICP-QMS-CRI) was evaluated. The behavior of several elements (Ba, Cd, Co, Cr, Cu, Li, Mn, Mo, Pb, Sb, V and Zn) was studied by introducing H2 or He through the skimmer and sampler cones of the CRI device and by using In, Rh and Sc as internal standards. Certified reference material of trace elements in water (NIST 1643e) was used to evaluate the performance of the method. A vinegar sample and mixed food diet standard reference material were directly introduced into the equipment as complex matrices for Cr and V determinations. Improvements in accuracy and precision were attained combining both strategies. The introduction of H2 through the skimmer cone was the best way to overcome polyatomic ions formation and to improve SBR and BEC values for several elements. The use of Sc as internal standard improved the performance of ICP-QMS-CRI.