Spontaneous oscillation of oxy- and deoxy- hemoglobin changes with a phase difference throughout the occipital cortex of newborn infants observed using non-invasive optical topography

• Published in: Neuroscience letters Vol. 282; no. 1; pp. 101 - 104
• Main Authors: Taga, Gentaro, Konishi, Yukuo, Maki, Atsushi, Tachibana, Tatsushi, Fujiwara, Michiyuki, Koizumi, Hideaki
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 17.03.2000; Elsevier
• Subjects: Biological and medical sciences; Cerebral blood volume; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges; deoxyhemoglobin; Female; Fundamental and applied biological sciences. Psychology; Hemoglobins - metabolism; Humans; Infant; Male; Near-infrared light spectroscopy; Newborn; Non-linear dynamics; Occipital cortex; Occipital Lobe - metabolism; Optical topography; Oscillation; oxyhemoglobin; Oxyhemoglobins - metabolism; Sleep - physiology; Spectroscopy, Near-Infrared; Vertebrates: nervous system and sense organs; Newborn; Near-infrared light spectroscopy; Occipital cortex; Oscillation; Non-linear dynamics; Cerebral blood volume; Optical topography; Human; Oxyhemoglobin; Blood volume; Central nervous system; Non invasive method; Hemoglobin; Optical method; Infant; Oxygenation; Brain (vertebrata)
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/S0304-3940(00)00874-0

We investigated spontaneous changes in the cerebral oxygenation state of infants during quiet sleeping by using a form of multi-channel near-infrared spectroscopy: non-invasive optical topography. Eight infants born at 32–39 weeks were studied at postconceptional term age (38–43 weeks). Spatially synchronized oscillations of changes in the concentration of oxy- and deoxy- hemoglobin ([oxy–Hb] and [deoxy–Hb]) were observed throughout the occipital cortex. Time series analysis based on the theory of non-linear oscillators showed that the mean periods of the oscillation for each infant ranged from 11 to 18 s. The phase lag of [oxy–Hb] relative to [deoxy–Hb] was stable at about 3π/4. This phase difference may result from interplay between the vasomotion and the oxygen consumption in relation to brain activity.