Inflammation in autoimmunity: receptors for IgG revisited

• Published in: Trends in Immunology Vol. 22; no. 9; pp. 510 - 516
• Main Authors: Dijstelbloem, Hilde M, Kallenberg, Cees G.M, van de Winkel, Jan G.J
• Format: Book Review Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2001
• Subjects: AFc receptors; Animals; autoimmunity; Autoimmunity - immunology; erythematosus; Fc gamma receptor; Humans; immune complex; Immunoglobulin G - immunology; immunotherapy; inflammation; Inflammation - immunology; Mice; mononuclear phagocyte system; polymorphism; Receptors, IgG - immunology; Signal Transduction - immunology; systemic lupus; Fc gamma receptor; Structural Biology; Cell biology; erythematosus; polymorphism; systemic lupus; Immunology; autoimmunity; inflammation; immune complex; immunotherapy; Genetics; mononuclear phagocyte system
• ISSN: 1471-4906; 1471-4981
• DOI: 10.1016/S1471-4906(01)02014-2

During the past decade, our knowledge of Fc receptor interactions in inflammation has increased dramatically owing to the availability of single and multiple Fc-receptor-deficient mice. The deletion of activating Fcγ receptors protects against inflammation in models of immune-complex-mediated diseases, whereas the deletion of inhibitory Fcγ receptors triggers increased susceptibility to immune-complex-induced inflammation. These new insights have a profound impact on our understanding of inflammation in autoimmune diseases, such as systemic lupus erythematosus (SLE). Comprehending the complex interactions between activating and inhibitory Fcγ receptors might lead to new therapeutic approaches for human diseases, including SLE.