Development of Noninvasive Technology of Stereotaxic Radioablation Using Linear Accelerators for the Treatment of Life-Threatening Ventricular Tachycardias in Experiment

• Published in: Bulletin of experimental biology and medicine Vol. 172; no. 5; pp. 612 - 616
• Main Authors: Vaskovskii, V. A., Taimasova, I. A., Artyukhina, E. A., Golanov, A. V., Revishvili, A. Sh
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2022; Springer; Springer Nature B.V
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Cardiac arrhythmia; Care and treatment; Cell Biology; Drug dosages; Drug therapy; Esophagus; Experiments; Feasibility studies; Heart; Internal Medicine; Laboratory Medicine; Medical research; Pathology; Radiation therapy; Septum; Software; Tachycardia; Tumors; Ventricle; ventricular tachycardia; stereotactic radioablation; noninvasive arrhythmology
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-022-05445-y

We developed a new technique of noninvasive stereotactic radioablation for the treatment of life-threatening tachyrhythmias. The study is performed on pigs ( Sus scrofa domesticus ). The zones of planned exposure were atrioventricular node (heart loading dose 40 Gy) and the apex of the left ventricle with a part of the interventricular septum (35 Gy) in animal No. 1 and atrioventricular node (45 Gy) and free wall of the left ventricle (40 Gy) in animal No. 2. The study was conducted on the Varian TrueBeam linear accelerator. The planned follow-up duration was 6 months. Delivery of 40 Gy to the atrioventricular node did not lead to persistent electrophysiological effect due to the development of transient third-degree atrioventricular block. The dose of 45 Gy resulted in permanent third-degree atrioventricular block followed by development of ventricular standstill on day 21 of observation. Histological examination confirmed transmurality and high precision of performed intervention.