Incorporating mechanical strain in organs-on-a-chip: Lung and skin

In the last decade, the advent of microfabrication and microfluidics and an increased interest in cellular mechanobiology have triggered the development of novel microfluidic-based platforms. They aim to incorporate the mechanical strain environment that acts upon tissues and in-vivo barriers of the...

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Bibliographic Details
Published inBiomicrofluidics Vol. 12; no. 4; pp. 042207 - 42221
Main Authors Guenat, Olivier T., Berthiaume, François
Format Journal Article
LanguageEnglish
Published United States American Institute of Physics 01.07.2018
AIP Publishing LLC
Subjects
Actuation
Epithelium
Microfluidics
Organs
Platforms
Skin
SPECIAL TOPIC: BIO-TRANSPORT PROCESSES AND DRUG DELIVERY IN PHYSIOLOGICAL MICRO-DEVICES
Strain
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Summary:In the last decade, the advent of microfabrication and microfluidics and an increased interest in cellular mechanobiology have triggered the development of novel microfluidic-based platforms. They aim to incorporate the mechanical strain environment that acts upon tissues and in-vivo barriers of the human body. This article reviews those platforms, highlighting the different strains applied, and the actuation mechanisms and provides representative applications. A focus is placed on the skin and the lung barriers as examples, with a section that discusses the signaling pathways involved in the epithelium and the connective tissues.
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ISSN:1932-1058
1932-1058
DOI:10.1063/1.5024895