Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid have less global and regional brain atrophy

• Published in: Journal of neuroimmunology Vol. 274; no. 1; pp. 149 - 154
• Main Authors: Ferreira, Daniel, Voevodskaya, Olga, Imrell, Kerstin, Stawiarz, Leszek, Spulber, Gabriela, Wahlund, Lars-Olof, Hillert, Jan, Westman, Eric, Karrenbauer, Virginija Danylaité
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.09.2014
• Subjects: Adult; Allergy and Immunology; Atrophy - cerebrospinal fluid; Atrophy - immunology; Atrophy - pathology; Brain - immunology; Brain - pathology; Brain atrophy; Brain Diseases - cerebrospinal fluid; Brain Diseases - immunology; Brain Diseases - pathology; Cerebrospinal fluid; Disability Evaluation; Female; Humans; Magnetic Resonance Imaging; Male; Medicin och hälsovetenskap; Middle Aged; MRI; Multiple Esclerosis; Multiple Sclerosis, Chronic Progressive - cerebrospinal fluid; Multiple Sclerosis, Chronic Progressive - immunology; Multiple Sclerosis, Chronic Progressive - pathology; Multiple Sclerosis, Relapsing-Remitting - cerebrospinal fluid; Multiple Sclerosis, Relapsing-Remitting - immunology; Multiple Sclerosis, Relapsing-Remitting - pathology; Multivariate analyses; Multivariate Analysis; Neurology; Oligoclonal bands; Oligoclonal Bands - cerebrospinal fluid; Oligoclonal Bands - immunology; Multivariate analyses; Multiple Esclerosis; Oligoclonal bands; Cerebrospinal fluid; MRI; Brain atrophy
• ISSN: 0165-5728; 1872-8421; 1872-8421
• DOI: 10.1016/j.jneuroim.2014.06.010

Abstract To investigate whether multiple sclerosis (MS) patients with and without cerebrospinal fluid (CSF) oligoclonal immunoglobulin G bands (OCB) differ in brain atrophy. Twenty-eight OCB-negative and thirty-five OCB-positive patients were included. Larger volumes of total CSF and white matter (WM) lesions; smaller gray matter (GM) volume in the basal ganglia, diencephalon, cerebellum, and hippocampus; and smaller WM volume in corpus callosum, periventricular-deep WM, brainstem, and cerebellum, were observed in OCB-positives. OCB-negative patients, known to differ genetically from OCB-positives, are characterized by less global and regional brain atrophy. This finding supports the notion that OCB-negative MS patients may represent a clinically relevant MS subgroup.