Feline Leukemia Virus DNA Vaccine Efficacy Is Enhanced by Coadministration with Interleukin-12 (IL-12) and IL-18 Expression Vectors

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Published inJournal of Virology Vol. 75; no. 18; pp. 8424 - 8433
Main Authors Hanlon, L, Argyle, D, Bain, D, Nicolson, L, Dunham, S, Golder, M C, McDonald, M, McGillivray, C, Jarrett, O, Neil, J C, Onions, D E
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.09.2001
Subjects
Adjuvants, Immunologic
Animals
Cats
Cell Line
DNA, Viral - immunology
env gene
Feline leukemia virus
Fusion Proteins, gag-pol - genetics
Fusion Proteins, gag-pol - immunology
gag gene
Gene Expression
Genetic Vectors
Humans
Interleukin-12 - administration & dosage
Interleukin-12 - genetics
Interleukin-12 - immunology
Interleukin-18 - administration & dosage
Interleukin-18 - genetics
Interleukin-18 - immunology
Leukemia Virus, Feline - genetics
Leukemia Virus, Feline - immunology
Pathogenesis and Immunity
pol gene
Recombination, Genetic
Retroviridae Infections - prevention & control
Tumor Virus Infections - prevention & control
Vaccination
Vaccines, DNA - administration & dosage
Vaccines, DNA - immunology
Viral Vaccines - administration & dosage
Viral Vaccines - immunology
Virion - physiology
Virus Assembly - physiology
Virus Latency
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Corresponding author. Mailing address: Department of Veterinary Pathology, University of Glasgow, Bearsden, Glasgow G61 1QH, United Kingdom. Phone: 44-141-330-6012. Fax: 44-141-330-5602. E-mail: lh40w@udcf.gla.ac.uk.
Present address: Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee University, Dundee DD1 9SY, United Kingdom.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.75.18.8424-8433.2001