Assessment of Myocardial Perfusion and Fatty Acid Metabolism in a Patient With Churg-Strauss Syndrome Associated With Eosinophilic Heart Disease

Churg-Strauss syndrome is characterized by asthma, eosinophilia and systemic necrotizing vasculitis; cardiac involvement (ie, eosinophilic heart disease) is the major cause of morbidity and mortality, although there are no reports of an association between left ventricular dysfunction because of eos...

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Published inCirculation Journal Vol. 68; no. 6; pp. 595 - 598
Main Authors Shikama, Nobuaki, Nakagawa, Tomoo, Takiguchi, Yasuo, Aotsuka, Nobuyuki, Kuwabara, Yoichi, Komiyama, Nobuyuki, Terano, Takashi, Hirai, Akira
Format Journal Article
LanguageEnglish
Published Japan The Japanese Circulation Society 01.06.2004
Subjects
123I BMIPP scintigraphy
201Tl scintigraphy
Aged
Cardiomyopathy, Dilated
Churg-Strauss syndrome
Churg-Strauss Syndrome - diagnosis
Churg-Strauss Syndrome - metabolism
Churg-Strauss Syndrome - physiopathology
Coronary Circulation
Disease Progression
Echocardiography
Electrocardiography
Eosinophilia
Eosinophilic heart disease
Fatty Acids - metabolism
Heart Diseases - blood
Heart Diseases - metabolism
Heart Diseases - pathology
Humans
Male
Myocardial fatty acid metabolism
Myocardial perfusion
Time Factors
Tomography, Emission-Computed, Single-Photon
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Summary:Churg-Strauss syndrome is characterized by asthma, eosinophilia and systemic necrotizing vasculitis; cardiac involvement (ie, eosinophilic heart disease) is the major cause of morbidity and mortality, although there are no reports of an association between left ventricular dysfunction because of eosinophilic heart disease and myocardial blood flow or myocardial fatty acid metabolism. A patient presented with Churg-Strauss syndrome associated with eosinophilic heart disease that had progressed to dilated cardiomyopathy. Coronary angiography, thallium-201 (201Tl) and iodine-123 β-methyl-iodophenyl pentadecanoic acid (123I BMIPP) myocardial single photon emission computed tomography (SPECT) were performed to evaluate left ventricular dysfunction. Although coronary angiography was normal and 201Tl SPECT showed no apparent image defect, 123I BMIPP SPECT showed diffuse decreased accumulation, excepting the apex. The left ventricular dysfunction in patients with eosinophilic heart disease is associated with impaired myocardial fatty acid metabolism rather than with impaired myocardial blood flow. (Circ J 2004; 68: 595 - 598)
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ISSN:1346-9843
1347-4820
DOI:10.1253/circj.68.595