Melanin-Concentrating Hormone (MCH) Involvement in Pentylenetetrazole (PTZ)-Induced Seizure in Rat and Guinea Pig

• Published in: Peptides (New York, N.Y. : 1980) Vol. 18; no. 7; pp. 1095 - 1097
• Main Authors: Knigge, K.M, Wagner, J.E
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 1997
• Subjects: 6-Hydroxydopamine; Animals; Convulsants - toxicity; Female; Guinea Pigs; Hypothalamic Hormones - pharmacology; Hypothalamic Hormones - physiology; Male; Melanin-concentrating hormone; Melanins - pharmacology; Melanins - physiology; Neurons - physiology; Oxidopamine - toxicity; Pentylenetetrazole; Pentylenetetrazole - toxicity; Pituitary Hormones - pharmacology; Pituitary Hormones - physiology; Rats; Rats, Sprague-Dawley; Seizure; Seizures - etiology; Seizures - physiopathology; Species Specificity; Pentylenetetrazole; Seizure; Melanin-concentrating hormone; 6-Hydroxydopamine
• ISSN: 0196-9781; 1873-5169
• DOI: 10.1016/S0196-9781(97)00036-3

KNIGGE, K. M. AND J. E. WAGNER. Melanin-concentrating hormone (MCH) involvement in pentylenetetrazole (PTZ)-induced seizure in rat and guinea pig. PEPTIDES 18(7) 1095–1097, 1997.—Intraperitoneal injection of 60 mg/kg of pentylenetetrazole (PTZ) induced seizure in rats, but was subthreshold and did not result in seizure in guinea pigs. Three days after intracerebroventricular (ICV) injection of 75 μg 6-hydroxydopamine (6-OHDA) in guinea pigs, PTZ induced seizures similar to those seen in rats. In both rats and 6-OHDA-treated guinea pigs, ICV injection of melanin-concentrating hormone (MCH) 15 min before PTZ prevented seizure activity. These results suggest that MCH-containing neurons may participate in the neural circuits involved in expression of PTZ-induced seizure.