MicroRNA directly modulates cardiac ion channel

A novel binding mechanism between a microRNA and an inward-rectifier potassium channel has been discovered. MiR-1 directly modulates the function of K ir 2.1 to maintain cardiac homeostasis, and disruption to this relationship predisposes the heart to a greater risk of arrhythmogenesis.

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Bibliographic Details
Published inNature reviews cardiology Vol. 18; no. 5; p. 308
Main Author Fitzpatrick, Ciarán Martin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.05.2021
Nature Publishing Group
Subjects
692/4019/592/75/29
692/420/2489/144
Action potentials (Electrophysiology)
Arrhythmia
Binding sites (Biochemistry)
Biological control systems
Cardiac Imaging
Cardiac Surgery
Cardiology
Cardiovascular research
Development and progression
Health aspects
Heart
Humans
Ion channels
Ion Channels - genetics
Medicine
Medicine & Public Health
MicroRNA
MicroRNAs
MicroRNAs - genetics
Physiological aspects
Research Highlight
United Kingdom
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Summary:A novel binding mechanism between a microRNA and an inward-rectifier potassium channel has been discovered. MiR-1 directly modulates the function of K ir 2.1 to maintain cardiac homeostasis, and disruption to this relationship predisposes the heart to a greater risk of arrhythmogenesis.
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ISSN:1759-5002
1759-5010
DOI:10.1038/s41569-021-00540-5