Organochlorine pesticides accumulation and breast cancer: A hospital-based case–control study

• Published in: Tumor biology Vol. 39; no. 5; p. 1010428317699114
• Main Authors: He, Ting-Ting, Zuo, An-Jun, Wang, Ji-Gang, Zhao, Peng
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.05.2017; Sage Publications Ltd; IOS Press
• Subjects: Adipose tissue; Adipose Tissue - chemistry; Adipose Tissue - pathology; Adult; Aged; Authorship; Breast cancer; Breast Neoplasms - chemically induced; Breast Neoplasms - chemistry; Breast Neoplasms - pathology; Case-Control Studies; Chlorobenzenes - isolation & purification; Chlorobenzenes - toxicity; Chromatography; Chromatography, Gas; Contamination; Epidermal growth factor; ErbB-2 protein; Estrogens; Etiology; Female; Gas chromatography; Health risk assessment; Hexachlorocyclohexane; Hormones; Humans; Hydrocarbons, Chlorinated - isolation & purification; Hydrocarbons, Chlorinated - toxicity; Immunohistochemistry; Lindane - isolation & purification; Lindane - toxicity; Metabolites; Middle Aged; Neoplasms - chemically induced; Neoplasms - chemistry; Neoplasms - pathology; Organochlorine pesticides; PCB; Pesticides; Pesticides - isolation & purification; Pesticides - toxicity; Polychlorinated biphenyls; Polychlorinated Biphenyls - isolation & purification; Polychlorinated Biphenyls - toxicity; Progesterone; Risk factors; Statistical analysis; United States > US; China; case-control study; organochloride pesticides; Breast cancer
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1177/1010428317699114

The aim of this study is to detect the accumulation status of organochlorine pesticides in breast cancer patients and to explore the relationship between organochlorine pesticides contamination and breast cancer development. We conducted a hospital-based case–control study in 56 patients with breast cancer and 46 patients with benign breast disease. We detected the accumulation level of several organochlorine pesticides products (β-hexachlorocyclohexane, γ-hexachlorocyclohexane, polychlorinated biphenyls-28, polychlorinated biphenyls-52, pentachlorothioanisole, and pp′-dichlorodiphenyldichloroethane) in breast adipose tissues of all 102 patients using gas chromatography. Thereafter, we examined the expression status of estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 (HER2), and Ki-67 in 56 breast cancer cases by immunohistochemistry. In addition, we analyzed the risk of breast cancer in those patients with organochlorine pesticides contamination using a logistic regression model. Our data showed that breast cancer patients suffered high accumulation levels of pp′-dichlorodiphenyldichloroethane and polychlorinated biphenyls-52. However, the concentrations of pp′-dichlorodiphenyldichloroethane and polychlorinated biphenyls-52 were not related to clinicopathologic parameters of breast cancer. Further logistic regression analysis showed polychlorinated biphenyls-52 and pp′-dichlorodiphenyldichloroethane were risk factors for breast cancer. Our results provide new evidence on etiology of breast cancer.