Fibroblast growth factor receptors in breast cancer

• Published in: Tumor Biology Vol. 39; no. 5; p. 1010428317698370
• Main Authors: Wang, Shuwei, Ding, Zhongyang
• Format: Book Review Journal Article
• Language: English
• Published: London, England SAGE Publications 01.05.2017; Sage Publications Ltd; IOS Press
• Subjects: Acids; Angiogenesis; Authorship; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Cell growth; Embryogenesis; Female; Fibroblast growth factor receptors; Fibroblasts; Genes; Genetic Association Studies; Genetic diversity; Growth factor receptors; Growth factors; Homeostasis; Humans; Immunoglobulins; Kinases; Ligands; Molecular Targeted Therapy; Mutation; Pathogenesis; Physiology; Receptor mechanisms; Receptor, Fibroblast Growth Factor, Type 1 - genetics; Receptor, Fibroblast Growth Factor, Type 2 - genetics; Receptor, Fibroblast Growth Factor, Type 3 - genetics; Receptor, Fibroblast Growth Factor, Type 4 - genetics; Receptor, Fibroblast Growth Factor, Type 5 - genetics; Receptors, Fibroblast Growth Factor - antagonists & inhibitors; Receptors, Fibroblast Growth Factor - genetics; Roles; Signal transduction; Signal Transduction - genetics; Structure-function relationships; Tyrosine; breast cancer; genetics; therapeutic strategy; Fibroblast growth factor receptor
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1177/1010428317698370

Fibroblast growth factor receptors are growth factor receptor tyrosine kinases, exerting their roles in embryogenesis, tissue homeostasis, and development of breast cancer. Recent genetic studies have identified some subtypes of fibroblast growth factor receptors as strong genetic loci associated with breast cancer. In this article, we review the recent epidemiological findings and experiment results of fibroblast growth factor receptors in breast cancer. First, we summarized the structure and physiological function of fibroblast growth factor receptors in humans. Then, we discussed the common genetic variations in fibroblast growth factor receptors that affect breast cancer risk. In addition, we also introduced the potential roles of each fibroblast growth factor receptors isoform in breast cancer. Finally, we explored the potential therapeutics targeting fibroblast growth factor receptors for breast cancer. Based on the biological mechanisms of fibroblast growth factor receptors leading to the pathogenesis in breast cancer, targeting fibroblast growth factor receptors may provide new opportunities for breast cancer therapeutic strategies.