Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [11 C]( R )-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analyses
Abstract Introduction [11 C]( R )-Rolipram is a selective radioligand for positron emission tomography (PET) imaging of phosphodiesterase 4, an enzyme that metabolizes 3′,5′-cyclic adenosine monophosphate. The aim of this study was to estimate the human radiation absorbed dose of the radioligand bas...
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Published in | Nuclear medicine and biology Vol. 35; no. 4; pp. 493 - 500 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.05.2008
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Subjects | |
Online Access | Get full text |
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Summary: | Abstract Introduction [11 C]( R )-Rolipram is a selective radioligand for positron emission tomography (PET) imaging of phosphodiesterase 4, an enzyme that metabolizes 3′,5′-cyclic adenosine monophosphate. The aim of this study was to estimate the human radiation absorbed dose of the radioligand based on its biodistribution in both monkeys and humans. Methods Whole-body PET images were acquired for 2 h after injecting [11 C]( R )-rolipram in eight healthy humans and three monkeys. The simple method of using a single two-dimensional (2D) planar image was compared to more time-consuming methods that used two (bisected) or four (quadrisected) tomographic images in the anteroposterior direction. Results Effective dose was 4.8 μGy/MBq based on 2D planar images. The effective dose was only slightly lower by 1% and 5% using the bisected and quadrisected images, respectively. Nevertheless, the two tomographic methods may have more accurately estimated the exposure of some organs (e.g., kidneys) that are asymmetrically located in the body or have radioactivity that appears to overlap on 2D planar images. Monkeys had a different biodistribution pattern compared to humans (e.g., greater urinary excretion) such that their data overestimated the effective dose in humans by 40%. Conclusions The effective dose of [11 C]( R )-rolipram was modest and comparable to that of other11 C-labeled radioligands. The simple and far less time-consuming 2D planar method provided accurate and somewhat more conservative estimates of effective dose than the two tomographic methods. Although monkeys are commonly used to estimate human radiation exposures, their data gave a considerable overestimation for this radioligand. |
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ISSN: | 0969-8051 1872-9614 |
DOI: | 10.1016/j.nucmedbio.2008.02.004 |