Current histological diagnosis of lymphomatoid granulomatosis
The current histological criteria for the diagnosis of lymphomatoid granulomatosis (LYG) are reviewed and summarized. The majority of patients present with multiple bilateral nodules involving the lung. Key histologic features necessary for the diagnosis include a mixed mononuclear cell infiltrate t...
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Published in | Modern pathology Vol. 25; no. Suppl 1; pp. S39 - S42 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
New York
Nature Publishing Group US
01.01.2012
Elsevier Limited |
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Online Access | Get full text |
ISSN | 0893-3952 1530-0285 1530-0285 |
DOI | 10.1038/modpathol.2011.149 |
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Abstract | The current histological criteria for the diagnosis of lymphomatoid granulomatosis (LYG) are reviewed and summarized. The majority of patients present with multiple bilateral nodules involving the lung. Key histologic features necessary for the diagnosis include a mixed mononuclear cell infiltrate that shows vascular infiltration, appreciable numbers of T-cells, and variable numbers of CD20-positive B cells that show positivity for EBER by
in situ
hybridization. |
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AbstractList | The current histological criteria for the diagnosis of lymphomatoid granulomatosis (LYG) are reviewed and summarized. The majority of patients present with multiple bilateral nodules involving the lung. Key histologic features necessary for the diagnosis include a mixed mononuclear cell infiltrate that shows vascular infiltration, appreciable numbers of T-cells, and variable numbers of CD20-positive B cells that show positivity for EBER by in situ hybridization. The current histological criteria for the diagnosis of lymphomatoid granulomatosis (LYG) are reviewed and summarized. The majority of patients present with multiple bilateral nodules involving the lung. Key histologic features necessary for the diagnosis include a mixed mononuclear cell infiltrate that shows vascular infiltration, appreciable numbers of T-cells, and variable numbers of CD20-positive B cells that show positivity for EBER by in situ hybridization. The current histological criteria for the diagnosis of lymphomatoid granulomatosis (LYG) are reviewed and summarized. The majority of patients present with multiple bilateral nodules involving the lung. Key histologic features necessary for the diagnosis include a mixed mononuclear cell infiltrate that shows vascular infiltration, appreciable numbers of T-cells, and variable numbers of CD20-positive B cells that show positivity for EBER by in situ hybridization.The current histological criteria for the diagnosis of lymphomatoid granulomatosis (LYG) are reviewed and summarized. The majority of patients present with multiple bilateral nodules involving the lung. Key histologic features necessary for the diagnosis include a mixed mononuclear cell infiltrate that shows vascular infiltration, appreciable numbers of T-cells, and variable numbers of CD20-positive B cells that show positivity for EBER by in situ hybridization. |
Author | Colby, Thomas V |
Author_xml | – sequence: 1 givenname: Thomas V surname: Colby fullname: Colby, Thomas V email: colby.thomas@mayo.edu organization: Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona |
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Cites_doi | 10.1080/10428190500284262 10.1097/PAS.0b013e3181fd8781 10.1097/00000478-199408000-00001 10.1111/j.1365-2559.1996.tb01415.x 10.1016/S0046-8177(72)80005-4 10.1097/00000478-199511000-00011 10.1002/1097-0142(197901)43:1<360::AID-CNCR2820430151>3.0.CO;2-8 10.1159/000237745 10.1182/blood.V87.11.4531.bloodjournal87114531 10.1182/blood.V72.5.1674.1674 |
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Title | Current histological diagnosis of lymphomatoid granulomatosis |
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