Current histological diagnosis of lymphomatoid granulomatosis

The current histological criteria for the diagnosis of lymphomatoid granulomatosis (LYG) are reviewed and summarized. The majority of patients present with multiple bilateral nodules involving the lung. Key histologic features necessary for the diagnosis include a mixed mononuclear cell infiltrate t...

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Bibliographic Details
Published inModern pathology Vol. 25; no. Suppl 1; pp. S39 - S42
Main Author Colby, Thomas V
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.01.2012
Elsevier Limited
Subjects
692/699/67/1990/291/1621/1915
692/700/139/422
B-Lymphocytes - immunology
B-Lymphocytes - pathology
Cells
Epstein-Barr virus
Herpesvirus 4, Human - immunology
Humans
Hybridization
Laboratory Medicine
long-course-article
Lung Neoplasms - diagnosis
Lung Neoplasms - immunology
Lung Neoplasms - pathology
Lymphoma
Lymphomatoid Granulomatosis - diagnosis
Lymphomatoid Granulomatosis - immunology
Lymphomatoid Granulomatosis - pathology
Medicine
Medicine & Public Health
Nervous system
Pathology
T-Lymphocytes - immunology
T-Lymphocytes - pathology
United States > US
lung
EBV
LYG
lymphomatoid granulomatosis
lymphoma
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Summary:The current histological criteria for the diagnosis of lymphomatoid granulomatosis (LYG) are reviewed and summarized. The majority of patients present with multiple bilateral nodules involving the lung. Key histologic features necessary for the diagnosis include a mixed mononuclear cell infiltrate that shows vascular infiltration, appreciable numbers of T-cells, and variable numbers of CD20-positive B cells that show positivity for EBER by in situ hybridization.
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ISSN:0893-3952
1530-0285
1530-0285
DOI:10.1038/modpathol.2011.149