Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity

Highlight ► This work shows that microglial cells express functional serotonin receptors linked to modulation of migration and phagocytic activity in vitro and in situ.

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Bibliographic Details
Published inBrain, behavior, and immunity Vol. 26; no. 3; pp. 419 - 428
Main Authors Krabbe, Grietje, Matyash, Vitali, Pannasch, Ulrike, Mamer, Lauren, Boddeke, Hendrikus W.G.M, Kettenmann, Helmut
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.03.2012
Subjects
Adenosine Triphosphate - physiology
Allergy and Immunology
Animals
Animals, Newborn
Brain - cytology
Brain - physiology
Cell Movement - physiology
Cells, Cultured
Chemotaxis - physiology
Focal lesion
Mice
Microglia
Microglia - physiology
Phagocytosis
Phagocytosis - physiology
Psychiatry
Receptor
Receptors, Serotonin - physiology
RNA, Messenger
Serotonin
Serotonin - physiology
Focal lesion
Serotonin
Receptor
Phagocytosis
Microglia
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Summary:Highlight ► This work shows that microglial cells express functional serotonin receptors linked to modulation of migration and phagocytic activity in vitro and in situ.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2011.12.002