The First Whole Genome Sequencing of Agaricus bitorquis and Its Metabolite Profiling

, an emerging wild mushroom with remarkable biological activities and a distinctive oversized mushroom shape, has gained increasing attention in recent years. Despite its status as an important resource of wild edible fungi, knowledge about this mushroom is still limited. In this study, we used the...

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Published inJournal of fungi (Basel) Vol. 9; no. 4; p. 485
Main Authors Zhao, Chunhua, Feng, Xi-Long, Wang, Zhen-Xin, Qi, Jianzhao
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.04.2023
MDPI
Subjects
Agaricus bitorquis
comparative genome
Cytochrome
edible mushroom
Error correction & detection
Fruit bodies
Fungi
Genes
Genomes
Genomics
Metabolism
Metabolites
Mitochondria
mitogenome
Mushrooms
Nucleotide sequence
Phylogeny
Proteins
Whole genome sequencing
China
Agaricus bitorquis
edible mushroom
mitogenome
comparative genome
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Summary:, an emerging wild mushroom with remarkable biological activities and a distinctive oversized mushroom shape, has gained increasing attention in recent years. Despite its status as an important resource of wild edible fungi, knowledge about this mushroom is still limited. In this study, we used the Illumina NovaSeq and Nanopore PromethION platforms to sequence, de novo assemble, and annotate the whole genome and mitochondrial genome (mitogenome) of the strain BH01 isolated from Bosten Lake, Xinjiang Province, China. Using the genome-based biological information, we identified candidate genes associated with mating type and carbohydrate-active enzymes in . Cluster analysis based on P450 of basidiomycetes revealed the types of P450 members of . Comparative genomic, mitogenomic, and phylogenetic analyses were also performed, revealing interspecific differences and evolutionary features of and . In addition, the molecular network of metabolites was investigated, highlighting differences in the chemical composition and content of the fruiting bodies of and . The genome sequencing provides a comprehensive understanding and knowledge of and the genus mushrooms. This work provides valuable insights into the potential for artificial cultivation and molecular breeding of , which will facilitate the development of in the field of edible mushrooms and functional food manufacture.
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ISSN:2309-608X
2309-608X
DOI:10.3390/jof9040485