Properties of zinc releasing surfaces for clinical applications

Two series of glasses of general formula (2-p) SiO2.1.1Na2O.CaO.pP2O5.xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when c...

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Bibliographic Details
Published inJournal of biomaterials applications Vol. 22; no. 6; p. 505
Main Authors Lusvardi, G, Malavasi, G, Menabue, L, Menziani, M C, Pedone, A, Segre, U, Aina, V, Perardi, A, Morterra, C, Boccafoschi, F, Gatti, S, Bosetti, M, Cannas, M
Format Journal Article
LanguageEnglish
Published England 01.05.2008
Subjects
Animals
Biocompatible Materials - chemistry
Cell Adhesion
Cell Line
Cell Proliferation
Focal Adhesions
Glass - chemistry
Materials Testing
Mice
Osteoblasts - cytology
Osteoblasts - physiology
Surface Properties
Zinc - chemistry
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Summary:Two series of glasses of general formula (2-p) SiO2.1.1Na2O.CaO.pP2O5.xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when cultured on them. The resulted good cell adhesion and growth, along with nonsignificant changes of the focal contacts, allow the authors to indicate HZ5 and HP5Z5 glasses as the ones having optimal ratio of Zn/P to maintain acceptable cell behavior, comparable to the bioactive glass (Bioglass) used as a control; results are also rationalized by means of three-dimensional models derived by molecular dynamic simulations, with decomposition and conversion rates optimized with respect to the parent Hench's Bioglass.
ISSN:0885-3282
1530-8022
DOI:10.1177/0885328207079731