The Role of Cancer and Somatic Stem Cells in the Anti-Inflammatory and Antitumor Effects of Aconitum baicalense Extract on Experimental Breast Cancer

• Published in: Bulletin of experimental biology and medicine Vol. 175; no. 2; pp. 254 - 259
• Main Authors: Pershina, O. V., Ermakova, N. N., Pakhomova, A. V., Zhukova, M. A., Pan, E. S., Sandrikina, L. A., Krupin, V. A., Rybalkina, O. Yu, Kogai, L. V., Kubatiev, A. A., Morozov, S. G., Dygai, A. M., Skurikhin, E. G.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2023; Springer; Springer Nature B.V
• Subjects: Aconitum; Analysis; Angiogenesis; Anti-inflammatory drugs; Antitumor activity; Biomedical and Life Sciences; Biomedicine; Bone marrow; Breast cancer; Cancer; Cell Biology; Drug dosages; Epithelial cells; Hematopoietic stem cells; Hemopoiesis; Inflammation; Internal Medicine; Laboratory animals; Laboratory Medicine; Mammary gland; Medical research; Metastasis; N-Methyl-N-nitrosourea; Neutrophils; Pathology; Pharmacology; Prevention; Progenitor cells; Regenerative medicine; Stem cells; Tumor cells; Tumors; Vascularization; N-methyl-N-nitrosourea; breast cancer; cancer stem cells; somatic stem cells; Aconitum baicalense
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-023-05845-8

We studied the effects of the extract of the terrestrial part of Aconitum baicalense in BALB/c female mice at the early stages after the injection of N-methyl-N-nitrosourea (MNU). The extract reduced inflammatory activity and tumor growth in the mammary gland. The antitumor and anti-inflammatory effects of the extract are based on the inhibition of cancer stem cells, hematopoietic stem cells, and hematopoietic progenitor cells that promote inflammation. The extract of A. baicalense disrupted the recruitment of epithelial progenitor cells and angiogenesis precursors to the mammary gland preventing neovascularization and transformation of epithelial cells into tumor cells.