Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses

• Published in: Tumor biology Vol. 39; no. 6; p. 1010428317705850
• Main Authors: Fang, Yantian, Ma, Minzhe, Wang, Jiangli, Liu, Xiaowen, Wang, Yanong
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.06.2017; Sage Publications Ltd; IOS Press
• Subjects: Adenocarcinoma; Adult; Aged; Antigens; Authorship; Bioinformatics; Biomarkers, Tumor - biosynthesis; Biomarkers, Tumor - genetics; Biotechnology; Breast cancer; Cancer therapies; Carcinogenesis - genetics; Cell cycle; Cell division; Cell growth; Chemotherapy; Circular RNA; Colorectal cancer; Female; Gastric cancer; Gastric Mucosa - metabolism; Gastric Mucosa - pathology; Gene expression; Gene Expression Regulation, Neoplastic; Humans; Hybridization; Kinases; Lung cancer; Lymphatic system; Male; Medical diagnosis; Metastases; Metastasis; Middle Aged; miRNA; Mucosa; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - pathology; Ontology; Proteins; Radiation therapy; RNA - biosynthesis; RNA - genetics; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; Therapeutic applications; Tumorigenesis; United States > US; Kyoto Encyclopedia of Genes and Genomes; gene ontology; Gastric cancer; circular RNA
• ISSN: 1010-4283; 1423-0380
• DOI: 10.1177/1010428317705850

Gastric cancer is one of the most common tumors of the digestive system. Here, analysis of the expression profiles of circular RNAs in advanced gastric adenocarcinoma and adjacent normal mucosa tissues revealed differential expression of 306 circular RNAs, among which 273 were predicted to exert regulatory effects on target microRNAs. The downstream pathway networks of circular RNA–microRNA were mapped and the node genes were identified. In particular, we found that the expression of hsa_circ_0058246 was elevated in tumor specimens of patients with poor clinical outcomes. Our collective findings indicate that circular RNAs play a critical role in gastric cancer tumorigenesis. Data from this study provide a new perspective on the molecular pathways underlying metastasis and recurrence of gastric cancer and highlight potential therapeutic targets that may contribute to more effective diagnosis and treatment of the disease.