Transcriptional regulation by hypoxia inducible factors

Abstract The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response...

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Published in	Critical reviews in biochemistry and molecular biology Vol. 49; no. 1; pp. 1 - 15
Main Authors	Dengler, Veronica L., Galbraith, Matthew D., Espinosa, Joaquín M.
Format	Journal Article
Language	English
Published	England Informa Healthcare USA, Inc 01.01.2014 Taylor & Francis
Subjects	Animals Chromatin histones Humans hydroxylation Hypoxia - genetics Hypoxia - metabolism hypoxia response element Hypoxia-Inducible Factor 1 - chemistry Hypoxia-Inducible Factor 1 - metabolism mediator p300 Protein Processing, Post-Translational RNA polymerase II RNA Polymerase II - metabolism Transcriptional Activation
Online Access	Get full text
ISSN	1040-9238 1549-7798 1549-7798
DOI	10.3109/10409238.2013.838205

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Abstract	Abstract The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.
AbstractList	The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their post-translational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia. The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia. Abstract The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia. The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.
Author	Galbraith, Matthew D. Dengler, Veronica L. Espinosa, Joaquín M.
Author_xml	– sequence: 1 givenname: Veronica L. surname: Dengler fullname: Dengler, Veronica L. email: joaquin.espinosa@colorado.edu, joaquin.espinosa@colorado.edu organization: Howard Hughes Medical Institute & Department of Molecular, Cellular and Developmental Biology, The University of Colorado at Boulder, Boulder, CO, USA – sequence: 2 givenname: Matthew D. surname: Galbraith fullname: Galbraith, Matthew D. email: joaquin.espinosa@colorado.edu, joaquin.espinosa@colorado.edu organization: Howard Hughes Medical Institute & Department of Molecular, Cellular and Developmental Biology, The University of Colorado at Boulder, Boulder, CO, USA – sequence: 3 givenname: Joaquín M. surname: Espinosa fullname: Espinosa, Joaquín M. email: joaquin.espinosa@colorado.edu, joaquin.espinosa@colorado.edu organization: Howard Hughes Medical Institute & Department of Molecular, Cellular and Developmental Biology, The University of Colorado at Boulder, Boulder, CO, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24099156$$D View this record in MEDLINE/PubMed
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Snippet	Abstract The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This... The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review...
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SubjectTerms	Animals Chromatin histones Humans hydroxylation Hypoxia - genetics Hypoxia - metabolism hypoxia response element Hypoxia-Inducible Factor 1 - chemistry Hypoxia-Inducible Factor 1 - metabolism mediator p300 Protein Processing, Post-Translational RNA polymerase II RNA Polymerase II - metabolism Transcriptional Activation
Title	Transcriptional regulation by hypoxia inducible factors
URI	https://www.tandfonline.com/doi/abs/10.3109/10409238.2013.838205 https://www.ncbi.nlm.nih.gov/pubmed/24099156 https://www.proquest.com/docview/1492674413 https://pubmed.ncbi.nlm.nih.gov/PMC4342852
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