Transcriptional regulation by hypoxia inducible factors

Abstract The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response...

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Published inCritical reviews in biochemistry and molecular biology Vol. 49; no. 1; pp. 1 - 15
Main Authors Dengler, Veronica L., Galbraith, Matthew D., Espinosa, Joaquín M.
Format Journal Article
LanguageEnglish
Published England Informa Healthcare USA, Inc 01.01.2014
Taylor & Francis
Subjects
Animals
Chromatin
histones
Humans
hydroxylation
Hypoxia - genetics
Hypoxia - metabolism
hypoxia response element
Hypoxia-Inducible Factor 1 - chemistry
Hypoxia-Inducible Factor 1 - metabolism
mediator
p300
Protein Processing, Post-Translational
RNA polymerase II
RNA Polymerase II - metabolism
Transcriptional Activation
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Summary:Abstract The cellular response to oxygen deprivation is governed largely by a family of transcription factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular mechanisms by which HIFs regulate the transcriptional apparatus to enable the cellular and organismal response to hypoxia. We discuss here how the various HIF polypeptides, their posttranslational modifications, binding partners and transcriptional cofactors affect RNA polymerase II activity to drive context-dependent transcriptional programs during hypoxia.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1040-9238
1549-7798
1549-7798
DOI:10.3109/10409238.2013.838205