Gastric emptying and small intestinal mucosal injury in rats

A technique was developed to produce small intestinal mucosal injury in vivo by perfusing the mid-small intestine of rats with HCl, NaOH, FeSO4, and AgNO3. Three hours following injury, gastric emptying and small intestinal transit were measured by examining the gastrointestinal distribution of a no...

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Bibliographic Details
Published inGastroenterology (New York, N.Y. 1943) Vol. 69; no. 6; p. 1246
Main Authors Kent, T H, Cannon, B, Reynolds, J A, Osborne, J W
Format Journal Article
LanguageEnglish
Published United States 01.12.1975
Subjects
Animals
Hydrochloric Acid
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Intestine, Small - drug effects
Intestine, Small - pathology
Intestine, Small - physiology
Iron
Male
Nausea - chemically induced
Necrosis
Parabiosis
Perfusion
Rats
Silver Nitrate
Sodium Hydroxide
Stomach - drug effects
Stomach - physiopathology
Vomiting - chemically induced
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Summary:A technique was developed to produce small intestinal mucosal injury in vivo by perfusing the mid-small intestine of rats with HCl, NaOH, FeSO4, and AgNO3. Three hours following injury, gastric emptying and small intestinal transit were measured by examining the gastrointestinal distribution of a non-absorbable radioisotope which had been placed in the stomach for 1 hour. There was a strong association between the villus injury produced by various concentrations of the injurious agents and the degree of gastric retention. Necrosis of villus tips, as produced by AgNO3, was sufficient to cause marked gastric retention. Injury to the small intestinal mucosa of one parabiotic rat did not produce gastric retention in the partner. It is concluded that injury to small intestinal villi is sufficient to induce gastric retention and that the effect is most likely nerve-mediated.
ISSN:0016-5085
DOI:10.1016/S0016-5085(19)32317-0