Prognostic Risk Models for the Development of Cardiovascular Dysfunction in Adolescents with Essential Hypertension

• Published in: Bulletin of experimental biology and medicine Vol. 166; no. 4; pp. 494 - 496
• Main Authors: Kosovtseva, A. S., Bairova, Т. А., Rychkova, L. V., Polyakov, V. M., Kolesnikova, L. I.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2019; Springer; Springer Nature B.V
• Subjects: Adolescent; Adolescents; Adrenergic receptors; Alleles; Anxiety; Anxiety - genetics; Anxiety - metabolism; Asian Continental Ancestry Group; Biochemistry; Biomedical and Life Sciences; Biomedicine; Catecholamines; Cell Biology; Cortisol; Dopamine D2 receptors; Dopamine receptors; Epistasis; Essential Hypertension - genetics; Essential Hypertension - pathology; Experimental Methods for Clinical Practice; Female; Gene Frequency - genetics; Genes; Genetic Predisposition to Disease - genetics; Genotype; Genotypes; Glucocorticoids; Humans; Hydrocortisone - metabolism; Hypertension; Internal Medicine; Laboratory Medicine; Male; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins - genetics; Norepinephrine transporter; Pathology; Phenols (Class of compounds); Polymorphism, Genetic - genetics; Prognosis; Psychological assessment; Psychological tests; Receptors, Adrenergic, alpha-2 - genetics; Receptors, Dopamine D2 - genetics; Risk assessment; Risk Factors; Russia; Structure-function relationships; Youth; Russia; prognostic models; essential hypertension; adolescents; catecholaminergic system; genes
• DOI: 10.1007/s10517-019-04380-9
• ISSN: 0007-4888

We present prognostic risk models for structural and functional cardiovascular disorders in Caucasian adolescents (Russians) with essential hypertension aged 14-17 years (15.92±1.12) taking into account biochemical (catecholamines and cortisol) and genetic parameters (carriage of polymorphic variants of α2A-adrenergic receptor gene ARA2A ( -1291С>G ), norepinephrine transporter NET ( -1287G>A ), and D2-dopamine receptor DRD2 ( -141C Ins/Del ) and the data of psychological testing. Prognostically significant risk factors for increased specific peripheral vascular resistance and variability of daytime systolic BP were a combination of [ CC+AA ] genotypes of ADRA2A -1291C>G and NET -1287G>A polymorphisms, cortisol level, anxiety, and proneness to conflict. The combination of genotypes [ CC+GG+II ] of polymorphisms -1291C>G ADRA2A , -1287G>A NET and -141C Ins/Del DRD is prognostically significant, with the GG genotype NET being epistatic.