Prognostic Risk Models for the Development of Cardiovascular Dysfunction in Adolescents with Essential Hypertension
We present prognostic risk models for structural and functional cardiovascular disorders in Caucasian adolescents (Russians) with essential hypertension aged 14-17 years (15.92±1.12) taking into account biochemical (catecholamines and cortisol) and genetic parameters (carriage of polymorphic variant...
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Published in | Bulletin of experimental biology and medicine Vol. 166; no. 4; pp. 494 - 496 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
New York
Springer US
01.02.2019
Springer Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | We present prognostic risk models for structural and functional cardiovascular disorders in Caucasian adolescents (Russians) with essential hypertension aged 14-17 years (15.92±1.12) taking into account biochemical (catecholamines and cortisol) and genetic parameters (carriage of polymorphic variants of α2A-adrenergic receptor gene
ARA2A
(
-1291С>G
), norepinephrine transporter
NET
(
-1287G>A
), and D2-dopamine receptor
DRD2
(
-141C Ins/Del
) and the data of psychological testing. Prognostically significant risk factors for increased specific peripheral vascular resistance and variability of daytime systolic BP were a combination of [
CC+AA
] genotypes of
ADRA2A -1291C>G
and
NET -1287G>A
polymorphisms, cortisol level, anxiety, and proneness to conflict. The combination of genotypes [
CC+GG+II
] of polymorphisms
-1291C>G ADRA2A
,
-1287G>A NET
and
-141C Ins/Del DRD
is prognostically significant, with the
GG
genotype
NET
being epistatic. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0007-4888 1573-8221 |
DOI: | 10.1007/s10517-019-04380-9 |